Chemistry Letters p. 651 - 654 (1980)
Update date:2022-08-03
Topics:
Hayashi, Sei-ichi
Nakai, Takeshi
Ishikawa, Nobuo
Defluorinative hydrolysis (or alcoholysis) of gem-difluoroolefins (1) easily prepared via the facile difluoromethylenation of carbonyl compounds afforded the carboxylic acids (or esters).The homologation method was applied to the synthesis of anti-inflammatory ibuprofen.Furthermore, defluorinative hydrolysis of monofluoroolefins obtained via the reduction of 1 gave the aldehydes.
View MoreHuludao Tianqi Shengye Chemical Co.,Ltd.
Contact:0086 429 2075777
Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China
Airsea(Taizhou) Pharmaceutical Limited(expird)
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Wuhan Kemi-Works Chemical Co., Ltd
website:http://www.kemiworks.com
Contact:86-27-85736489
Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Contact:+86-633-8332928
Address:No.1,Huanghai Yilu.Rizhao,Shandong
Doi:10.1021/ja01157a108
(1950)Doi:10.1016/j.tet.2004.06.031
(2004)Doi:10.1021/jo00315a031
(1981)Doi:10.1055/s-2005-865219
(2005)Doi:10.1002/ejoc.201901060
(2020)Doi:10.1021/ja047488e
(2004)
