Chemistry Letters p. 651 - 654 (1980)
Update date:2022-08-03
Topics:
Hayashi, Sei-ichi
Nakai, Takeshi
Ishikawa, Nobuo
Defluorinative hydrolysis (or alcoholysis) of gem-difluoroolefins (1) easily prepared via the facile difluoromethylenation of carbonyl compounds afforded the carboxylic acids (or esters).The homologation method was applied to the synthesis of anti-inflammatory ibuprofen.Furthermore, defluorinative hydrolysis of monofluoroolefins obtained via the reduction of 1 gave the aldehydes.
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