SYNTHESIS AND MOLECULAR STRUCTURE OF PROLAME, N-(3-HYDROXY-1,3,5(10)-ESTRATRIEN-17β-YL)-3-HYDROXYPROPYLAMINE; AN AMINO-ESTROGEN WITH PROLONGED ANTICOAGULANT AND BRIEF ESTROGENIC EFFECTS

Article abstract of DOI:10.1016/0039-128X(85)90044-3

The synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17β-yl)-3-hydroxypropylamine, is described.It was characterized by ir, nmr, mass spectrometry and chemical analysis.The crystal structure of this compound was determined by single-crystal x-ray diffraction.Prolame belongs to space group P2₁2₁2₁.Cell dimensions are: a = 8.356(2), b = 13.343(4) and c = 16.119(4) Angstroem.Z = 4; R = 4.1percent.