Green Chemistry
Paper
General procedure for the reusability of Pd(OAc)2–H2O–PEG
in the Suzuki coupling reaction of 1-bromo-4-nitrobenzene
with PhBF3K. A 25 mL round-bottom flask was charged with
1-bromo-4-nitrobenzene (0.5 mmol), PhBF3K (0.60 mmol),
Na2CO3 (1 mmol), Pd(OAc)2 (1 mol%), and H2O–PEG (3 : 3 g)
and the mixture was stirred at 80 °C for 1 h. Then the mixture
was cooled to room temperature, and extracted using diethyl
ether (4 × 10 mL). The residue (Pd(OAc)2–H2O–PEG) was sub-
jected to the next run of the Suzuki reaction by charging with
the same substrates (1-bromo-4-nitrobenzene (0.5 mmol),
PhBF3K (0.60 mmol), Na2CO3 (1 mmol)) under the same reac-
tion conditions. Water (0.5 mL) was added to the catalytic
system in the third, fifth and seventh runs. The combined
organic layer was concentrated under reduced pressure, and
the residue was isolated by chromatography on a silica gel
(300–400 mesh) column using petroleum and ethyl acetate to
afford the product.
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Financial support from the Natural Science Foundation of
Shandong Province (ZR2010BQ022, ZR2010BL015, and
J10LB55) and Dezhou University (08RC14) is acknowledged.
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