ACS Medicinal Chemistry Letters
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Damblon, C.; Lassaux, P.; Papamicael, C.; Roberts, G. C.; Galleni,
purification, assay of inhibitory activity; determination of
MIC, and docking study. These materials are available free of
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AUTHOR INFORMATION
Corresponding Author
Tel/Fax: +8629-8153-5035.
E-mail: kwyang@nwu.edu.cn (K. W. Yang)
Author Contributions
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The manuscript was written through contributions of all
authors.
(16) Ullah, J. H.; Walsh, T. R.; Taylor, I. A.; Emery, D. C.; Verma,
C. S.; Gamblin, S. J.; Spencer, J. The crystal structure of the L1
metallo-beta-lactamase from Stenotrophomonas maltophilia at
1.7 A resolution. J. Mol. Biol. 1998, 284, 125-36.
(17) Fonseca, F.; Bromley, E. H. E.; Saavedra, M. J.; Correia, A.;
Spencer, J. Crystal Structure of Serratia fonticola Sfh-I: Activation
of the Nucleophile in Mono-Zinc Metallo-β-Lactamases. J. Mol.
Biol. 2011, 411, 951-9.
(18) Sharma, N.; Hu, Z.; Crowder, M. W.; Bennett, B.
Conformational changes in the metallo-beta-lactamase ImiS
during the catalytic reaction: an EPR spectrokinetic study of
Co(II)-spin label interactions. J. Am. Chem. Soc. 2008, 130, 8215-
22.
(19) Costello, A. L.; Sharma, N. P.; Yang, K. W.; Crowder, M. W.;
Tierney, D. L. X-ray absorption spectroscopy of the zinc-binding
sites in the class B2 metallo-beta-lactamase ImiS from
Aeromonas veronii bv. sobria. Biochemistry 2006, 45, 13650-8.
(20) Sharma, N. P.; Hajdin, C.; Chandrasekar, S.; Bennett, B.;
Yang, K. W.; Crowder, M. W. Mechanistic studies on the
mononuclear ZnII-containing metallo-beta-lactamase ImiS from
Aeromonas sobria. Biochemistry 2006, 45, 10729-38.
Funding Sources
This work was supported by grants 21272186 and 81361138018
(to K.W.Y.) from the National Natural Science Foundation of
China. Notes
The authors declare no competing financial interest.
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