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(
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Conclusions
1
1
In summary, we developed an effective and environmentally
friendly method for the synthesis of amides via copper-
catalyzed one-pot direct oxidative amidation between methyl-
arenes and amines. This method has combined methylarenes
oxidation and amide bond formation into one procedure, which
otherwise would follow two distinct steps. Using copper as
a catalyst and TBHP as the sole oxidant proved to be economical
too. What's more, the starting materials of the reaction are
abundant, economical and easily accessible, and the reaction
has a wide range of substrate scope.
1
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Acknowledgements
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407; (c) C. G. Subhash, S. Y. N. Joyce, A. M. Seayad,
This research has been supported by the National Natural
Science Foundation of China (Grant No. 21522604, U1463201
and 21402240); the youth in Jiangsu Province Natural Science
Fund (Grant No. BK20150031 and BY2014005-03); a Project
Funded by the Priority Academic Program Development of
Jiangsu Higher Education Institutions (PAPD).
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