10.1002/anie.201806963
Angewandte Chemie International Edition
COMMUNICATION
compound in good yield (0.29 g, 87% yield). See Supporting Information
for detailed experimental procedures.
Keywords: radical reactions • hydrogen atom transfer • C–H
functionalization • synthetic methods • regioselectivity
[15] See Supporting Information for further details.
[16] The same ratio of products was obtained at lower concentrations (0.1 M),
suggesting that the minor 1,6-product is not the result of background
intermolecular functionalization.
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[14] If desired, the thiocarbamylsulfenamide may be used in crude form in the
substrate
synthesis.
For
example,
N-
((methyl(phenyl)carbamothioyl)thio)-N-isopropylhexanamide
(the
substrate used in Table 1, entry 1) was prepared using crude N-
(((isopropylamino)thio)carbonothioyl)-N-methylaniline (0.48 g, 2.0 mmol,
2.0 equiv), hexanoyl chloride (0.14 mL, 1.0 mmol, 1.0 equiv), and
pyridine (81 μL, 1.0 mmol, 1.0 equiv) in CH2Cl2 (4.0 mL) to give the title
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