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Acknowledgements
Dedicated to Professor Jurgen Henrich Fuhrhop on the
¨
occasion of his 64th birthday.
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iodine (5mol%) in toluene (10mL) was stirred at reflux.
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was filtered off and washed with cold methanol to remove
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methanol. The obtained products 4(a–n) were identified by
comparison with authentic samples and by 1H and 13C
NMR and their melting points.
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Spectral data for compound 4a: 1H NMR (DMSO-d6,
500MHz) d: 0.90–1.40 (m, 30H, CH3, CH3CH2O,
(CH3)2CH); 2.49–2.76 (m, 4H, CH(CH3)2); 4.09 (q, 2H,
OCH2CH3, J = 7.0Hz); 4.41 (q, 2H, H05, J = 3.30Hz);
4.63 (q, 1H, H04, J = 3.16Hz); 5.20 (s, 1H, CH); 5.79 (t,
1H, H03, J = 6.50Hz); 6.27 (d + t, 2H, H01 and H02,
J = 7.97, 4.68Hz); 7.45 (d, 2H, ArH, J = 8.2Hz); 7.8 (s,
1H, NH, pyrimidinone); 8.02 (d, 2H, ArH, J = 8.24Hz);
9.25 (s, 1H, amide NH, guanosine); 9.21 (s, 1H, NH,
pyrimidinone); 12.11 (br, s, 1H, N0H, guanosine); 13C
NMR (DMSO-d6, 125MHz): 14.0, 17.6, 18.4, 18.5, 18.8,
18.9, 33.7, 33.9, 36.6, 53.7, 59.1, 62.2, 70.7, 72.6, 78.9, 87.6,
112.1, 115.1, 121.7, 129.9, 130.1, 134.0, 137.0, 146.2, 147.4,
148.5, 155.4, 159.1, 165.2, 175.5, 176.4, 177.4, 178.7; MS
(FAB, pos): m/z C40H51N7O12; calculated: 821.4; found:
822.2 (M+H)+, 844.2 (M+Na)+.
9. (a) Narsaiah, A. V.; Basak, A. K.; Nagaiah, K. Synthesis
2004, 1253–1256; (b) Varla, R.; Alam, M.; Adapa, S. R.
18. Sessler, J. L.; Wang, B.; Harriman, A. J. Am. Chem. Soc.
1995, 117, 704–714.