Tetrahedron p. 2391 - 2404 (2018)
Update date:2022-08-30
Topics:
Noland, Wayland E.
Brown, Christopher D.
Zabronsky, Abigail E.
Tritch, Kenneth J.
Twenty-nine examples of 2-(9H-carbazol-1-yl)anilines were obtained in yields from 27 to 95% by refluxing 2,3′-biindolyl (1 equiv.) and ketones (1 equiv.) in ethanolic HCl. Alkyl, cyclic, and aryl ketones were found to be compatible with this method, however, aldehydes are not. Because the reaction proceeds by addition of the carbonyl C atom to the biindolyl 3-position, this method has high regioselectivity. One example is presented of bridging the two N atoms in the carbazolylaniline product with an acetaldehyde synthon to give a benzodiazepino[lm]carbazole. Also, one example is given of installing a dimethylamino group at the α-position of the starting ketone to give an indolo[3,2-c]carbazole.
View MoreContact:86-574-83851061 86-574-87083208
Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Luoyang Aoda chemical Co.,Ltd.
Contact:+86-379-67518785 67516588
Address:MiaoWan industry district,YanShi City,Henan,China
Contact:86-15588110016
Address:LINYI CITY,SHANDONG PROVINCE,CHINA
zhangjiagang bonded areas banggao co;ltd
website:http://www.shunchangchem.com
Contact:0086-13921972933
Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Contact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
Doi:10.1002/chem.200400284
(2004)Doi:10.1371/journal.pone.0198121
(2018)Doi:10.1007/BF00488161
()Doi:10.1039/c8dt02032a
(2018)Doi:10.1002/ejic.201300600
(2013)Doi:10.1016/0040-6031(93)80058-I
(1993)