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O
O
O
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(EtO)2CO, NaH
O
78%
Cl
Cl
22
23
O
LiAlH4 41%
Cl
O
S
OH
O
Cl
MsCl, NEt3
87%
OH
O
S
O
O
Cl
Cl
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25
24
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Med. Chem. 2014, 57, 1344.
+
S–
K
N
N
+
S–
K
CS2, KOH,
DMSO, 2 h, rt
N
N
92%
N
N
13
14
KOH, MeCN, 3 h, rt
N
S
Cl
N
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N
S
Cl
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26
Scheme 3 Synthesis of the luliconazole analogue 26 with a dithiane ring
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Acknowledgment
The authors gratefully acknowledge the excellent synthetic contribu-
tion of Amelie Tessier.
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Supporting Information
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Supporting information for this article is available online at
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References and Notes
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© Georg Thieme Verlag Stuttgart · New York — Synlett 2018, 29, A–D