M. Sánchez et al. / Life Sciences 79 (2006) 1349–1356
1355
more studies are necessary to visualize for a clear structure–
activity relationship of this triterpenes.
gratefully acknowledged. M. Sánchez thanks the Universidad
de Talca for a Doctoral Grant.
Re-epithelialization is a key process in the ulcer-healing after
mucosal injury. To restore the mucosal integrity the filling of the
mucosal defect with proliferating and migrating epithelial and
connective tissue cells is necessary (Tarnawski et al., 2001). In a
previous work it has been reported that oleanolic acid promotes
the healing of acetic acid-induced chronic gastric ulcers in rats
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2
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Financial support by FONDECYT, Grant N° 1030792 and
the Programa de Productos Bioactivos, Universidad de Talca is