New Journal of Chemistry
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Journal Name
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ARTICLE
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The X-ray data have been deposited at the Cambridge
There are no conflicts of interest to declare.
DOI: 10.1039/C9NJ00574A
Crystallographic Data Centre with the CCDC number 1846970
.
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Acknowledgements
Antifungal activity assay
The authors gratefully acknowledge the financial support of
the National Natural Science Foundation of China (No.
31772209) and the Fundamental Research Funds for the
Central Universities of China (No. KYTZ201604).
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The target compounds were tested for antifungal acitivity
against F. graminearum, B. cinerea and R. solani in vitro by
mycelium growth rate method.35,40 The tested fungus strains
were provided by the Laboratory of Plant Disease Control at
Nanjing Agricultural University. Every sample was dissolved in
DMSO and mixed with PSA (potato sucrose agar) medium. An
equal dose of DMSO in medium was used as the blank control.
Meanwhile, the commercial agricultural fungicides
carbendazim and penthiopyrad were tested as the positive
control at the same concentration. Each 15 mL medium was
poured into a 9 cm petri plate with 3 replicates. The fungi were
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Notes and references
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3D-QSAR study method
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Conclusions
The substituted phenylhydrazone moieties were introduced to
4-position of 5-chloro-pyrazoles to design and synthesize a
series of novel pyrazole derivatives as potent antifungal agents.
The target compounds were well characterized by the
spectroscopy and single crystal X-ray diffraction. The bioassay
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obvious fungicidal activity against the tested plant pathogenic
fungi. The compounds 7c and 8d showed most potent
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μg mL–1 against B. cinerea and R. solani, respectively, which are
superior than the corresponding control drugs carbendazim
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Conflicts of interest
This journal is © The Royal Society of Chemistry 20xx
J. Name., 2013, 00, 1-3 | 10
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