Bioorganic and Medicinal Chemistry Letters p. 1577 - 1582 (1999)
Update date:2022-08-11
Topics:
Ciuffreda, Pierangela
Casati, Silvana
Santaniello, Enzo
The selective acylation of the hydroxy groups of the nucleosides inosine 1a and 2'-deoxyinosine lb has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents; starting from the 5'-acetyl derivative of 2'-deoxyinosine, compound 5a, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine 1c has been achieved.
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