Tetrahedron Letters p. 2397 - 2400 (1994)
Update date:2022-08-16
Topics:
Hassner, Alfred
Falb, Eliezer
Nudelman, Abraham
Albeck, Amnon
Gottlieb, Hugo E.
A new route for asymmetric aza-sugar analogs starting with L-serine and utilizing an intramolecular oxime olefin cycloaddition has been successfully developed. A member of this family of branched chain sugar amino di(hydroxymethyl) pyrrolidines (1 and 2) exhibits selective inhibition of α-glucosidase, while no inhibition of β-glucosidase was detected.
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