Organic Letters
Letter
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2764.
Michael addition and NHC-catalyzed Stetter reaction relay
sequence. The reaction can be scaled up easily, and the
synthetic potentials of the obtained products are illustrated by
selective transformations into more complex skeletons. We
believe this approach will find more applications since it
provides ready access to synthetically useful bicyclic diones.
ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Experimental details and analytical data (NMR, HPLC,
IR, ESI-HRMS) for all new compounds (PDF)
X-ray data for compound 6d (CIF)
X-ray data for compound 9 (CIF)
X-ray data for compound 10 (CIF)
AUTHOR INFORMATION
■
Corresponding Author
ORCID
Notes
The authors declare no competing financial interest.
(9) (a) Wang, Y.; Yu, T.-Y.; Zhang, H.-B.; Luo, Y.-C.; Xu, P.-F.
Angew. Chem., Int. Ed. 2012, 51, 12339. (b) Gu, Y.; Wang, Y.; Yu, T.-
Y.; Liang, Y.-M.; Xu, P.-F. Angew. Chem., Int. Ed. 2014, 53, 14128.
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Chem. Soc. 2009, 131, 13628. (b) Filloux, C. M.; Lathrop, S. P.; Rovis,
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1596.
ACKNOWLEDGMENTS
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We are grateful to the NSFC (21632003, 21372105, and
21572087), the “111”program from the MOE of P. R. China,
and Syngenta Company for financial support. We also thank
Prof. Zhi-Xiang Yu from Peking University for helpful
suggestions.
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