PAPER
Synthesis of C-5-Substituted 2'-Deoxyuridine in Water
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1H NMR (400 MHz, CD3OD): d = 2.36 (d, J = 6.4 Hz, 1 H), 2.37 (d,
J = 6.4 Hz, 1 H), 3.76 (dd, J5¢–5¢ = 12 Hz, J5¢–4¢ = 3.2 Hz, 1 H), 3.84
(dd, J5¢–5¢ = 12 Hz, J5¢–4¢ = 2.8 Hz, 1 H), 3.97 (m, 1 H), 4.47 (m,
1 H), 6.39 (t, J = 6.4 Hz, 1 H), 7.47 (m, 2 H), 7.68 (dd, J = 8.4,
1.6 Hz, 1 H), 7.85 (m, 3 H), 8.11 (br s, 1 H), 8.44 (s, 1 H).
13C NMR (101 MHz, CD3OD): d = 41.8, 62.6, 72.1, 86.9, 89.1,
116.0, 127.1, 127.2, 127.3, 128.3, 128.6, 128.8, 129.3, 131.9, 134.2,
134.8, 140.2, 151.9, 164.8.
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MS (ESI): m/z = 377.05 [M + Na]+, 353.10 [M – H]–.
HRMS (ESI): m/z [M + Na]+ calcd for C19H18N2O5Na: 377.1113;
found: 377.1108.
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Acknowledgment
This work was supported by the regional program of Région Picar-
die, France.
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