Chemical and Pharmaceutical Bulletin p. 1998 - 2000 (1995)
Update date:2022-08-16
Topics:
Negi
Yamanaka
Komatsu
Tsuruoka
Tsukada
Minami
The esterification of Δ3-cephem-4-carboxylic acid sodium salt (1) with 1-iodoethyl isopropyl carbonate always afforded the Δ2 cephem ester (3) as an inseparable minor component. However, in the course of formamido cleavage reaction, the 7-amino-Δ2-cephem ester (5) was observed to be less stable than the Δ3 cephera ester (4), which led us to develop a practical synthetic process for Δ3 cephem esters, including a key intermediate of E1101, a new oral cephalosporin.
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