Tetrahedron p. 4157 - 4170 (1985)
Update date:2022-08-11
Topics:
Minisci, Francesco
Citterio, Attilio
Vismara, Elena
Giordano, Claudio
The synthetic interest of the direct substitution of protonated heteroaromatic bases by nucleophilic carbon-centered radicals is furtheron developed by the following new achievements: i) utilization of the redox system N(+)H3OH/Ti(III) in several solvents; ii) utilization of benzoyl peroxide in alcohols; iii) carbamoylation by HCONH2 and H2O2 in the presence of catalytic amounts of Fe(II).These systems allow to obtain either substitution till now tried without success or reactions of industrial interest.Polar effects play a dominat role in determining reactivity, selectivity and synthetic applications; in particular the role of the strongly nucleophilic intermediate radicals of pyridinyl type in the rearomatization step is emphasized.
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Doi:10.1055/s-1999-3645
(1999)Doi:10.1016/S0040-4039(97)01108-8
(1997)Doi:10.1080/00304940509355407
(2005)Doi:10.1248/cpb.41.292
(1993)Doi:10.1021/op050047a
(2005)Doi:10.1021/jo01369a021
(1954)