A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A

Article abstract of DOI:10.1016/0968-0896(96)00076-4

A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A anhydride (1) is reported. The imidazopyridinium bromide S obtained from the reaction of 2-bromopalmitoyl chloride and 2-aminopyridine was reacted with maleic anhydride in the presence of NaOAc/AcOH to form 1 in 62% overall yield in three steps.