Zn2+ -promoted hydrolysis of 3',5'-dinucleoside monophosphates and polyribonucleotides. The effect of nearest neighbours on the cleavage of phosphodiester bonds

Article abstract of DOI:10.1080/07328319608002466

Pseudo first-order rate constants for the Zn²⁺ -promoted cleavage of 15 different dinucleoside monophosphates, 4 different ribo homopolymers and RNA III from baker's yeast have been determined. Furthermore, the distribution of various nucleosides at the 3'- and 5'-terminus of the oligomeric hydrolysis products of RNA has been quantified. On these bases, the effect of nearest neighbours on the metal-ion-promoted hydrolysis of the internucleosidic phosphodiester bonds of RNA is discussed.

Full text of DOI:10.1080/07328319608002466

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Nucleosides and Nucleotides
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2+
Zn -Promoted Hydrolysis of 3′,5′-
Dinucleoside Monophosphates and
Polyribonucleotides. The Effect of
Nearest Neighbours on the Cleavage of
Phosphodiester Bonds
a
a
Satu Kuusela & Harri Lönnberg
a
Department of Chemistry , University of Turku , FIN-20014, Turku,
Finland
Published online: 20 Aug 2006.
2+
To cite this article: Satu Kuusela & Harri Lönnberg (1996) Zn -Promoted Hydrolysis of 3′,5′-
Dinucleoside Monophosphates and Polyribonucleotides. The Effect of Nearest Neighbours on
the Cleavage of Phosphodiester Bonds, Nucleosides and Nucleotides, 15:10, 1669-1678, DOI:
10.1080/07328319608002466
To link to this article: http://dx.doi.org/10.1080/07328319608002466
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