Enantioselective synthesis of curacin A. 2. Total synthesis of curacin A by condensation of C1-C7, C8-C17, and C18-C22 segments

Article abstract of DOI:10.1016/0040-4039(96)00031-7

Total synthesis of curacin A, a novel antimitotic antiproliferative antibiotic, was achieved by the connection of C1-C7, C8-C17, and C18-C22 segments by Julia coupling and iminoether condensation.