Chemo-enzymatic approach to the synthesis of each of the four isomers of α-alkyl-β-fluoroalkyl-substituted β-amino acids

Article abstract of DOI:10.1016/0957-4166(94)80163-0

Starting from easily available ethyl 2-methyl-4,4,4-trifluoroacetoacetate and benzylamine each of the four stereoisomers of α-methyl-β- trifluoromethyl-β-alanine have been synthesized in optically pure form via stereocontrolled chemo-enzymatic procedure i