Communication
Journal of Materials Chemistry B
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3. Conclusions
We have developed a double-locked phototrigger for a targeted
image-guided DDS. One- and two-photon excitation (1PE and
2PE) of the DDS rapidly activated increased uorescence in
living cells, which was employed for the real-time monitoring of
the prodrug and in vitro cellular imaging. Extended irradiation
of DDS resulted in release of the anticancer drug chlorambucil
with increased cytotoxicity towards the MDA-MB-231 line
compared to the free drug.
Acknowledgements
We wish to thank DST–SERB for nancial support, and DST–
FIST for 200 MHz NMR measurements. S.K. and M.G. are
grateful to IIT KGP for fellowships.
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