10.1002/ejoc.202000667
European Journal of Organic Chemistry
COMMUNICATION
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Scheme 5. Proposed mechanism for the copper(II)-promoted N-arylation of the
indolic side chain of tryptophan using triarylbismuthines.
In summary, we developed a simple and general procedure for
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Acknowledgements
This work was supported by Boehringer Ingelheim
Pharmaceuticals Inc. through a Scientific Advancement grant.
The authors also acknowledge the Natural Sciences and
Engineering Research Council of Canada (NSERC) and the
Centre in Green Chemistry and Catalysis (CGCC) for financial
support.
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Keywords: N-Arylation • Organobismuthines • Tryptophan •
Indole • Copper catalysis
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