Chemistry - A European Journal
10.1002/chem.201701627
COMMUNICATION
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5
resulted in the formation of SF -Sulfoxaflor as a mixture of two
pairs of diastereomers (~53/47 ratio; 74% yield) (Scheme 5).
This is the first example of bioactive molecule analog with SF
5
-
substituent located directly in heterocyclic ring.
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Scheme 5. Synthesis of SF -Sulfoxaflor.
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Acknowledgement. The authors wish to acknowledge helpful
discussions with Peter Maienfisch of Syngenta Crop Protection
AG regarding this research project.
Keywords: cross-coupling • nickel catalysis • photoredox
catalysis • decarboxylation • Sulfoxaflor
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