Tetrahedron p. 8597 - 8604 (1993)
Update date:2022-08-11
Topics:
Mauvais, Antony
Hetru, Charles
Roussel, Jean Pierre
Luu, Bang
Key Words: Ecdysone; C-22 Hydroxylase; Ecdysteroid inhibitor; Acetylenic inhibitor; Hydroboration. Several acetylenic derivatives of ecdysone were synthesized from pregnenolone.These compounds carry an acetylenic function at C-22 and were devised with the aim to inhibit the C-22 hydroxylation of ecdysone biosynthesis by a suicide-substrate mechanism.The five compounds synthesized inhibit the synthesis of ecdysone in the prothoracic glands of Locusta migratoria in vitro.
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