LETTER
One-Pot Synthesis of Pyrano- [2,3-d]pyrimidines and Pyrido[2,3-d]pyrimidines
285
Scheme 2
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plays the key role in the reaction as no desired compounds
were obtained in its absence. Acetic acid, which is re-
formed in the reaction, in turn catalyses the intermediate
to afford the cyclic adduct.
In conclusion, we have demonstrated a novel three-com-
ponent reaction under solvent-free conditions that offers
a simple and efficient route for the synthesis of highly
functionalised pyrano[2,3-d]pyrimidines, pyrido[2,3-
d]pyrimidines and pyrido[2,3-d]pyrimidine N-oxides of
biological importance in excellent yields. Furthermore,
the results delineated above have demonstrated that mi-
crowave-assisted multicomponent reaction in solvent-free
condition can substitute classical methods allowing easy
and rapid access to novel heterocycles of biological
significance, reducing the reaction times from hours to
minutes with improved yields.
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Synlett 2004, No. 2, 283–286 © Thieme Stuttgart · New York