Journal of Asian Natural Products Research p. 1063 - 1078 (2016)
Update date:2022-08-26
Topics:
Pavan Kumar, Ch.
Devi
Ashok Yadav
Rao Vadaparthi
Shankaraiah
Sowjanya
Jain, Nishant
Suresh Babu
As part of pharmacological–phytochemical integrated studies on medicinal plants from Indian flora, costunolide (1) and dehydrocostus lactone (2), were isolated as major phytochemicals from Saussurea lappa, a plant traditionally used in different Asian systems of medicine. A series of 1,4-disubstituted-1,2,3-triazoles conjugates were synthesized through diastereo selective Michael addition followed by regioselective Huisgen 1,3-dipolar cycloaddition reactions. All these triazolyl derivatives (5a–5j) & (7a–7j) were well characterized using modern spectroscopic techniques and evaluated for their anticancer activity against a panel of five human cancerous celllines. The results indicated that all the analogs displayed moderate cytotoxic activity.
View MoreXian Changyue Biological Technology Co., Ltd.
website:https://www.xachangyue.com/
Contact:+86-029-62886900
Address:Keji Road NO.70
Changzhou Hopschain Chemical Co.,Ltd
Contact:86-519-85528066
Address:Room 710, Unit A, Xingbei Development Mansion, Tongjiang Road, Changzhou City,213000, China
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
website:http://www.shydtec.com
Contact:86-21-57721279
Address:Science and Technology Park, Songjiang District, Shanghai, China
NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD
website:https://xdcchemical.com/
Contact:86-311-85758226
Address:North Industry Area, Wuji
shijiazhuang shuanglian chemical industry co.,ltd
Contact:0311-82190302
Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway,Shijiazhuang City
Doi:10.1080/10286020.2012.738675
(2012)Doi:10.1016/S0022-328X(01)00689-1
(2001)Doi:10.1002/ange.202009888
(2020)Doi:10.1016/S0925-8388(98)00586-6
(1998)Doi:10.1002/(SICI)1521-4184(199911)332:11<389::AID-ARDP389>3.0.CO;2-U
(1999)Doi:10.1016/j.molstruc.2013.07.011
(2013)