1128 Crystal Growth & Design, Vol. 10, No. 3, 2010
Miragaya et al.
Figure 8. Solvent surface of the neighbors next to S-2-butanol. For clarity, some atoms have not been considered and the surface is drawn in
two left and right halves.
Acknowledgment. The authors thank the Ministerio de
Ciencia y Tecnologıa, Spain, (Project MAT2006-61721) for
financial support. J.M. also thanks the Ministerio de Ciencia y
Tecnologıa, Spain, for a scholarship.
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Four steroid molecules are required to fully describe the
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a central role as it interacts with three of these steroid
molecules and with the S-2-butanol molecule which acts only
as a donor toward water; that is, it does not exhibit double
hooks (Figure 9).9,26 Each bile acid molecule is linked to three
other steroid molecules. This hydrogen bond network inter-
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network scheme and lengths are shown in Figure 9, all of them
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Conclusion
When AdCH2CA is recrystallized in racemic 2-butanol,
only the S-enantiomer is included in the bilayer structure of
the crystal, allowing the enantioresolution of the racemate by
isolation of crystals. The steroid molecules are disposed in
antiparallel orientation in the hydrophobic layer and parallel
in the hydrophilic one. The guest S-2-butanol exhibits a
chameleonic mimicry with the steroid bilayers suggesting that
this behavior can be further exploited in designing new host
molecules for the enantioresolution of other alkyl alcohols.
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