Relative hepatotoxicity of 2-(substituted phenyl)thiazoles and substituted thiobenzamides in mice: Evidence for the involvement of thiobenzamides as ring cleavage metabolites in the hepatotoxicity of 2-phenylthiazoles

Article abstract of DOI:10.1016/0378-4274(96)03646-6

The hepatotoxicity of the 3 isomers of para-substituted thiobenzamides and the 3 isomers of 2-(para-substituted phenyl)-4-methylthiazoles was evaluated in mice depleted of glutathione (GSH) by pretreatment with buthionine sulfoximine (BSO). In accordance