Structure-activity relationship analysis of substituted 4- quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides

Article abstract of DOI:10.1016/S0960-894X(99)00291-7

On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM.