Di-ddU-α-hydroxyphosphonate and α-hydroxy-α-methylphosphonates as potential prodrugs of antiviral nucleoside analogues

Article abstract of DOI:10.1080/07328319708006178

The synthesis of a potential new prodrug system for the antiviral nucleoside ddU 1 based on α-hydroxybenzylphosphonates 2 and 3 is described. In principle, 2, 3 are able to hydrolyze via different mechanisms yielding ddU H-phosphonate 4 or ddU monophosphate 5, respectively.