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Glycylglycine

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Name

Glycylglycine

EINECS 209-127-8
CAS No. 556-50-3 Density 1.337 g/cm3
PSA 92.42000 LogP -0.76290
Solubility Soluble in hot water Melting Point 262-264 °C
Formula C4H8N2O3 Boiling Point 453.2 °C at 760 mmHg
Molecular Weight 132.119 Flash Point 227.9 °C
Transport Information N/A Appearance white powder
Safety 24/25-26 Risk Codes 36
Molecular Structure Molecular Structure of 556-50-3 (Glycylglycine) Hazard Symbols IrritantXi
Synonyms

Diglycine;2-(Aminoacetamido)acetic acid;Glycine dipeptide;

Article Data 115

Glycylglycine Synthetic route

56-40-6

glycine

556-50-3

glycylglycine

Conditions
ConditionsYield
With silica gel In toluene for 20h; Heating;92.4%
With zeolite Na-BETA In water at 120℃; var. silicates and pH;
Multistep reaction;
With Sodium trimetaphosphate In aq. buffer at 37℃; under 225023 Torr; pH=10.7; Pressure; Temperature;
31972-52-8

Boc-Gly-Gly-OH

556-50-3

glycylglycine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane Large scale;84.9%
With trifluoroacetic acid In dichloromethane at -5℃;
208645-74-3

Gly-Gly-MCA

556-50-3

glycylglycine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; dipeptydyl-peptidase DPP5; sodium phosphate; sodium chloride In water at 37℃; for 0.5h; pH=7.0; Catalytic behavior; Enzymatic reaction;

tetrabutylphosphonium glycinate

5680-79-5

glycine ethyl ester hydrochloride

556-50-3

glycylglycine

Conditions
ConditionsYield
Stage #1: tetrabutylphosphonium glycinate; glycine ethyl ester hydrochloride at 60℃; for 3h; Inert atmosphere;
Stage #2: With acetic acid In chloroform at 20℃; for 3h;
54%
627-74-7

glycylglycine ethyl ester

556-50-3

glycylglycine

Conditions
ConditionsYield
With 15K(1+)*H(1+)*25H2O*O122P4W34Zr(16-); water; hydrogen chloride In water-d2 at 60℃; pH=5;
20238-94-2

glycylglycinamide

556-50-3

glycylglycine

Conditions
ConditionsYield
With 15K(1+)*H(1+)*25H2O*O122P4W34Zr(16-); water; hydrogen chloride In water-d2 at 60℃; pH=5;
2566-19-0

CbzGlyGly

556-50-3

glycylglycine

Conditions
ConditionsYield
With trifluoroacetic acid
With nitromethane; hydrogen bromide
With phosphonium iodide; acetic acid at 45 - 50℃; im Wasserstoff-Strom;
5893-07-2

N-tritylglycylglycine

556-50-3

glycylglycine

Conditions
ConditionsYield
With acetic acid
With ethanol; palladium Hydrogenation;
N--glycine

N--glycine

556-50-3

glycylglycine

Conditions
ConditionsYield
With ethanol; hydrazine hydrate
18409-49-9

N-carbamoyl-L-alanine

56-40-6

glycine

A

56-41-7

L-alanin

B

687-69-4

alanylglycine

C

556-50-3

glycylglycine

D

462-60-2

N-carbamoylglycine

Conditions
ConditionsYield
In phosphate buffer at 80℃; for 1272h; pH=6.8;

Glycylglycine Specification

The Glycylglycine, with the CAS registry number 556-50-3, is also known as [(Ammonioacetyl)amino]acetate. It belongs to the product categories of Biochemistry; Oligopeptides; Peptide Synthesis; Peptide. Its EINECS registry number is 209-127-8. This chemical's molecular formula is C4H8N2O3 and molecular weight is 132.12. Its IUPAC name is called 2-[(2-aminoacetyl)amino]acetic acid.

Physical properties of Glycylglycine: (1)ACD/LogP: -1.85; (2)ACD/LogD (pH 5.5): -4.34; (3)ACD/LogD (pH 7.4): -4.67; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.504; (12)Molar Refractivity: 29.3 cm3; (13)Molar Volume: 98.8 cm3; (14)Surface Tension: 60.1 dyne/cm; (15)Density: 1.337 g/cm3; (16)Flash Point: 227.9 °C; (17)Enthalpy of Vaporization: 78.1 kJ/mol; (18)Boiling Point: 453.2 °C at 760 mmHg; (19)Vapour Pressure: 1.78E-09 mmHg at 25°C.

Preparation: this chemical can be prepared by glycine and ethylenediamine. This reaction will need methanol.

Uses of Glycylglycine: it can be used to produce piperazine-2,5-dione at temperature of 150 - 160 °C. This reaction will need reagent diluted hydrochloric acid.

Glycylglycine is the dipeptide of glycine, making it the simplest peptide. Because of its low toxicity, it is useful as a buffer for biological systems with effective ranges between pH 2.5-3.8 and 7.5-8.9, however, it is only moderately stable for storage once dissolved. It is used in the synthesis of more complex peptides. The product is a biochemical reagents which is used for blood preservation and protein cytochrome C and injection of drug and stabilizer in biological research and medicine.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes. You must avoid contacting it with skin and eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(C(=O)NCC(=O)O)N
(2)InChI: InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
(3)InChIKey: YMAWOPBAYDPSLA-UHFFFAOYSA-N

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