- Granisetron
- Granisetron hydrochloride
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Cas Database |
| Name |
Granisetron hydrochloride |
EINECS | 634-603-0 |
| CAS No. | 107007-99-8 | Density | 1.33g/cm3 |
| PSA | 50.16000 | LogP | 3.44920 |
| Solubility | N/A | Melting Point |
290-292 °C |
| Formula | C18H25ClN4O | Boiling Point | 532 °C at 760 mmHg |
| Molecular Weight | 348.876 | Flash Point | 275.6 °C |
| Transport Information | N/A | Appearance | white to off-white crystalline solid |
| Safety | 26-36-37 | Risk Codes | 22-62-37/38-36/37/38-36 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride(9CI);BRL 43694A;Kytril;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride(1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, monohydrochloride, endo-; |
Article Data | 3 |
Granisetron hydrochloride Synthetic route
- 109889-09-0, 124998-65-8
granisetron
- 107007-99-8
granisetron hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water; isopropyl alcohol | 77% |
| With hydrogenchloride In water; toluene at 50 - 60℃; |
- 76272-41-8, 141650-55-7, 76272-56-5
endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
- 106649-02-9
1-methylindazole-3-carboxylic acid chloride
- 107007-99-8
granisetron hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride; triethylamine In dichloromethane |
- 107007-99-8
granisetron hydrochloride
- 109889-09-0, 124998-65-8
granisetron
| Conditions | Yield |
|---|---|
| With ammonia; water for 0.5h; Product distribution / selectivity; |
Granisetron hydrochloride Chemical Properties
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IUPAC Name: 1-Methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide hydrochloride
Empirical Formula: C18H25ClN4O
Molecular Weight: 348.8703
Flash Point: 275.6 °C
Enthalpy of Vaporization: 80.77 kJ/mol
Boiling Point: 532 °C at 760 mmHg
Vapour Pressure: 2.12E-11 mmHg at 25 °C
Appearance: White to Off-White Crystalline Solid
Melting Point: 290-292 °C
storage temp.: Room temp
Classification Code of Granisetron hydrochloride (CAS NO.107007-99-8): Anti-emetic; Drug / Therapeutic Agent; Mutation data; Reproductive Effect
Product Categories: Pharmaceutical material and intermeidates; Active Pharmaceutical Ingredients; API; Heterocyclic Compounds; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; Granisetron; Serotonin receptor; Serotonin
Granisetron hydrochloride Uses
Granisetron hydrochloride (CAS NO.107007-99-8) is used as an antiemetic.
Granisetron hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 3mg/kg (3mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING | Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992. |
| dog | LDLo | oral | 15mg/kg (15mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995. |
| mouse | LD50 | intravenous | 17mg/kg (17mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990. |
| mouse | LD50 | oral | 350mg/kg (350mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. | |
| rat | LD50 | intravenous | 14mg/kg (14mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990. |
| rat | LD50 | oral | 350mg/kg (350mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. |
Granisetron hydrochloride Safety Profile
Hazard Codes: 
Xn,
Xi
Risk Statements: 22-62-37/38-36/37/38-36
R22:Harmful if swallowed.
R62:Risk of impaired fertility.
R37/38:Irritating to respiratory system and skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
Safety Statements: 26-36-37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37:Wear suitable gloves.
RTECS: NK7882200
Granisetron hydrochloride Specification
Granisetron hydrochloride (CAS NO.107007-99-8), its Synonyms are 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide monohydrochloride ; Granisetron HCl ; Granisetron hydrochloride preservative free ; Kytril ; Kytril Injection ; endo-1-Methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide hydrochloride .
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