- GUANETHIDINE BISULFATE
- Guanethidine monosulfate
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| Name |
Guanethidine monosulfate |
EINECS | 211-442-0 |
| CAS No. | 645-43-2 | Density | N/A |
| PSA | 148.12000 | LogP | 2.29240 |
| Solubility | N/A | Melting Point |
276-281 °C |
| Formula | C10H22N4•H2O4S | Boiling Point | 345.6 °C at 760 mmHg |
| Molecular Weight | 296.44 | Flash Point | 162.8 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | S25;S36 | Risk Codes | R22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
2-(Octahydro-1-azocinyl)ethyl guanidine sulphate;Heptamethylenimine, 1-(2-guanidinoethyl)-;Guanethidine monosulfate [USAN];N-(2-Perhydroazocin-1-ylethyl)guanidine;Azocine, 1-((2-(aminoiminomethyl)amino)ethyl)octahydro-;(2-(Hexahydro-(2H)-azocin-1-yl)ethyl)guanidinium sulphate;Azocine, 1-(2-guanidinoethyl)octahydro-;Guanidine,[2-(hexahydro-1(2H)-azocinyl)- ethyl]-,sulfate (1:1);2-[2-(azocan-1-yl)ethyl]guanidine;Abapresin;Oktadin;Dopom;N-(2-Guanidino ethyl)heptamethylenimine sulfate;Eutensol;Esimil;Dopam;2-(1-N,N-Heptamethyleneimino)ethylguanidine;Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1);Guanethidinum [INN-Latin];Oktatenzin;Oktatensin;Ismelin(TN);Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-;Guanetidina [INN-Spanish];Octatensine;(2-(Hexahydro-1(2H)-azocinyl)ethyl) guanidine hydrogen sulfate;Sanotensin;2-[2-(azocan-1-yl)ethyl]guanidine; sulfuric acid;2-(1-Azacyclooctyl)ethylguanidine;Ismelin sulfate;Guanethidine sulfate;(2-(Octahydro-1-azocinyl)ethyl)guanidine;Ismelin;(2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (1:1); |
Guanethidine monosulfate Chemical Properties
The molecular structure of Guanethidine Monosulfate (CAS NO.645-43-2) :
IUPAC Name: 2-[2-(azocan-1-yl)ethyl]guanidine; sulfuric acid
Empirical Formula: C10H24N4O4S
Molecular Weight: 296.387
EINECS: 211-442-0
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 3
Polar Surface Area: 22.08Å2
Flash Point: 162.8 °C
Enthalpy of Vaporization: 58.97 kJ/mol
Boiling Point: 345.6 °C at 760 mmHg
Vapour Pressure: 6.09E-05 mmHg at 25°C
InChI
InChI=1/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
Smiles
C1CCCCCCN1CCNC(=N)N.S(O)(O)(=O)=O
Classification Code: Antihypertensive; Drug / Therapeutic Agent; Skin / Eye Irritant
Guanethidine monosulfate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 180mg/kg (180mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 353, 1972. | |
| mouse | LD50 | intravenous | 18500ug/kg (18.5mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 353, 1972. | |
| mouse | LD50 | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Archiv der Pharmazie Vol. 321, Pg. 57, 1988. |
Guanethidine monosulfate Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A human eye irritant. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Hazard Codes: 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 25-36
S25:Avoid contact with eyes.
S36:Wear suitable protective clothing.
RTECS: MF3150000
Guanethidine monosulfate Specification
Guanethidine monosulfate , with CAS number of 645-43-2, can be called Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (1:1) ; Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)- ; 2-(1-N,N-Heptamethyleneimino)ethylguanidine ; 2-[2-(azocan-1-yl)ethyl]guanidine; sulfuric acid ; (2-(Octahydro-1-azocinyl)ethyl)guanidine ; (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (1:1) . It should be stored in tightly closed container at room temperature. Guanethidine monosulfate (CAS NO.645-43-2) can be used to treat moderate and severe hypertension and renal hypertension, including that secondary to pyelonephritis, renal amyloidosis and renal artery stenosis.
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