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Hydrocortisone sodium succinate

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Name

Hydrocortisone sodium succinate

EINECS 204-725-5
CAS No. 125-04-2 Density N/A
PSA 141.03000 LogP 0.86260
Solubility H2O: 50 mg/mL Melting Point 169.0-171.2°
Formula C25H33NaO8 Boiling Point 685.5 °C at 760 mmHg
Molecular Weight 502.59 Flash Point 231.1 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 125-04-2 (Hydrocortisone sodium succinate) Hazard Symbols N/A
Synonyms

U 4905;Cortisol,21-(hydrogen succinate), monosodium salt (8CI);Cortisol, succinate, sodium salt (6CI);A-HydroCort;Buccalsone;Corlan;Cortisol hemisuccinate sodium salt;Cortisol sodium hemisuccinate;Cortisolsodium succinate;EF-Cortelan Soluble;Emi-Corlin;Flebocortid;Hydrocortisone21-hemisuccinate sodium salt;Hydrocortisone 21-succinate sodium salt;Hydrocortisone hemisuccinate sodium salt;Hydrocortisone sodiumsuccinate;Intracort;Nordicort;Oralsone;Sodium 17-hydroxycorticosterone 21-succinate;Sodium hydrocortisone 21-hemisuccinate;Solu-Cortef;Solu-Glyc;Hydrocortisone sodium succinate;

 

Hydrocortisone sodium succinate Specification

The Hydrocortisone sodium succinate, with the CAS registry number 125-04-2, is also known as 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt. Its EINECS registry number is 204-725-5. This chemical's molecular formula is C25H33NaO8 and molecular weight is 484.51449. Its IUPAC name is called sodium 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate. This chemical which is used as a pharmaceutical intermediate should be stored at - 20 °C. This chemical's classification codes are Drug / Therapeutic Agent; Glucocorticoid; Human Data; Reproductive Effect.

Physical properties of Hydrocortisone sodium succinate are: (1)ACD/LogP: 2.13; (2)#H bond acceptors: 8; (3)#H bond donors: 3; (4)#Freely Rotating Bonds: 9; (5)Flash Point: 231.1 °C; (6)Enthalpy of Vaporization: 114.97 kJ/mol; (7)Boiling Point: 685.5 °C at 760 mmHg; (8)Vapour Pressure: 9.36E-22 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].[O-]C(=O)CCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@@]3(/C(=C\C(=O)CC3)CC4)C
(2)InChI: InChI=1/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
(3)InChIKey: HHZQLQREDATOBM-HVZBPSDKBG

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo intravenous 1429ug/kg (1.429mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Medical Journal of Australia. Vol. 154, Pg. 782, 1991.
man TDLo intravenous 2857ug/kg (2.857mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA
Medical Journal of Australia. Vol. 154, Pg. 210, 1991.
mouse LD50 intraperitoneal 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 625, 1982.
rat LD50 intraperitoneal 1320mg/kg (1320mg/kg)   Drugs in Japan Vol. 6, Pg. 625, 1982.

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