- 70-00-8Trifluridine
- 70008-57-0Tetraethylammonium ((5beta)-3alpha,7alpha,12alpha)-trihydroxycholan-24-oate
- 70010-48-9Benzenamine,4-(2-thienyl)-
- 700-12-9Benzene,1,2,3,4,5-pentamethyl-
- 700-13-01,4-Benzenediol,2,3,5-trimethyl-
- 700-16-3Pentafluoropyridine
- 700-17-4Benzenamine,2,3,5,6-tetrafluoro-
- 70020-54-1Dibenz[b,f][1,4]oxazepine,2-chloro-8-methoxy-11-(4-methyl-1-piperazinyl)-
- 70024-40-7Methanone,[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-,hydrochloride, hydrate (1:1:2)
- 70024-48-5Benzenesulfonic acid,5-[[4-[bis(2-hydroxyethyl)amino]-6-methoxy-1,3,5-triazin-2-yl]amino]-2-[2-[4-[[4-methoxy-6-[(2-sulfoethyl)amino]-1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl]-(9CI)
Hot Products
- 700370-10-11-Sulfobutyl-3-methylimidazolium p-Toluenesulfonate
- 700-58-32-Adamantanone
- 7006-59-9EthanaMiniuM, 2-hydroxy-N,N-bis(2-hydroxyethyl)-N-Methyl-, chloride
- 70070-12-14-[(5,6-dimethoxy-3,4-dihydro-1H-isochromen-1-yl)methyl]morpholine hydrochloride
- 701258-20-05-bromo-2-chloro-N,N-dimethylbenzamide
- 701-44-01-methyl-6-oxo-pyridine-3-carboxamide
- 70161-44-3Sodium hydroxymethylglycinate
- 70198-29-7Butanedioic acid polymer with 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidineethanol
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Indole-3-carbinol |
EINECS | 211-836-2 |
| CAS No. | 700-06-1 | Density | 1.272 g/cm3 |
| PSA | 36.02000 | LogP | 1.66020 |
| Solubility | N/A | Melting Point |
96-99 °C(lit.) |
| Formula | C9H9NO | Boiling Point | 360.6 °C at 760 mmHg |
| Molecular Weight | 147.177 | Flash Point | 171.9 °C |
| Transport Information | N/A | Appearance | Off-white powder |
| Safety | 26-36 | Risk Codes | 36/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Indole-3-methanol(6CI,7CI,8CI);3-(Hydroxymethyl)indole;3-Indolylcarbinol;3-Indolylmethanol;Indinol;NSC 525801;Indole-3-methanol; |
Article Data | 37 |
Indole-3-carbinol Synthetic route
| Conditions | Yield |
|---|---|
| With sodium methylate for 8h; Heating; | 100% |
| With methanol; sodium hydrogencarbonate | |
| With sodium methylate |
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In methanol at 0℃; for 1h; | 100% |
| With formic acid In ethanol at 80℃; for 12h; Catalytic behavior; | 91% |
| With ammonia; calcium In tetrahydrofuran at -33℃; for 2h; other reagents: lithium, sodium, liq. ammonia; | 80% |
| Conditions | Yield |
|---|---|
| Stage #1: 3-methoxycarbonylindole With pentadec-3-en-2-one; trimethylsilyl trifluoromethanesulfonate; triphenylphosphine In dichloromethane at -78 - 0℃; for 1h; Inert atmosphere; Stage #2: With diisobutylaluminium hydride In hexane; dichloromethane at -78℃; Inert atmosphere; Stage #3: With potassium carbonate In methanol; hexane; dichloromethane at 20℃; for 0.5h; Inert atmosphere; | 84% |
- 487-89-8
Indole-3-carboxaldehyde
- 124-40-3
dimethyl amine
A
- 700-06-1
indole-3-carbinol
B
- 87-52-5
3-(Dimethylaminomethyl)indole
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; water In methanol at 55 - 60℃; for 2.5h; | A 25% B 74% |
- 487-89-8
Indole-3-carboxaldehyde
A
- 700-06-1
indole-3-carbinol
B
- 22259-53-6
3-aminomethylindole
C
- 93742-14-4
bis(indol-3-ylmethyl)amine
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; sodium tetrahydroborate In methanol at 14 - 18℃; for 20h; | A 72% B 9% C 13% |
- 487-89-8
Indole-3-carboxaldehyde
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
A
- 700-06-1
indole-3-carbinol
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In methanol at 20℃; for 1.5h; Leukardt-Wallach Amination; | A 30% B 49% |
- 87-51-4
indole-3-acetic acid
A
- 83-34-1
3-Methylindole
B
- 487-89-8
Indole-3-carboxaldehyde
C
- 700-06-1
indole-3-carbinol
D
- 59027-01-9
3-(3-methylindol-1-yl)methylindole
| Conditions | Yield |
|---|---|
| With 1,3,6,8-tetra-n-butylpyrimido<5,4-g>pteridine-2,4,5,7(1H,3H,6H,8H)-tetrone 10-oxide In acetonitrile for 0.0833333h; Irradiation; | A 14% B 36% C 12% D 8% |
| With 1,3,6,8-tetra-n-butylpyrimido<5,4-g>pteridine-2,4,5,7(1H,3H,6H,8H)-tetrone 10-oxide In acetonitrile for 0.166667h; Product distribution; Ambient temperature; Irradiation; depends on time and wavelength of irradiation and ratio of reacted compounds; |
- 17206-03-0
1-(1H-indol-3-yl)-N,N-dimethylmethanamine oxide
- 700-06-1
indole-3-carbinol
| Conditions | Yield |
|---|---|
| With sodium hydroxide; diethyl ether; water |
| Conditions | Yield |
|---|---|
| With sodium hydroxide; diethyl ether; water |
Indole-3-carbinol Chemical Properties
Molecular Structure of Indole-3-methanol (CAS NO.700-06-1):
Molecular Formula: C9H9NO
Molecular Weight: 147.1739
IUPAC Name: 1H-Indol-3-ylmethanol
CAS NO: 700-06-1
Appearance:white to off white crystals
Melting point: 96-99 °C
Index of Refraction: 1.705
Molar Refractivity: 44.97 cm3
Molar Volume: 115.6 cm3
Surface Tension: 61.7 dyne/cm
Density: 1.272 g/cm3
Flash Point: 171.9 °C
Enthalpy of Vaporization: 63.98 kJ/mol
Boiling Point: 360.6 °C at 760 mmHg
Vapour Pressure: 7.89E-06 mmHg at 25°C
Classification Code: Anticarcinogenic agents; Antineoplastic Agents; Protective Agents; Reproductive Effect
Synonyms: 3-Hydroxymethylindole ; 3-Indolylcarbinol ; 5-21-03-00045 (Beilstein Handbook Reference) ; AI3-60090 ; BRN 0121323 ; CCRIS 3261 ; EINECS 211-836-2 ; Indinol ; Indole 3 carbinol ; Indole-3-carbinol ; NSC 525801 ; 1H-Indole-3-methanol (9CI)
SMILES: OCc2c1ccccc1nc2
InChI: InChI=1/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
InChIKey: IVYPNXXAYMYVSP-UHFFFAOYAO
Std. InChI: InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
Std. InChIKey: IVYPNXXAYMYVSP-UHFFFAOYSA-N
Indole-3-carbinol Uses
Indole-3-methanol (CAS NO.700-06-1) can prevent the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. It has be shown to inhibit carcinogenesis in several animal species, but it enhances tumor incidence if administered at a post-initiation stage.
Indole-3-carbinol Production
Indole-3-methanol (CAS NO.700-06-1) naturally exists in vegetables such as cabbage, broccoli, brussels sprouts, and kale. It is also widely available in supplement form. In 1985,B Sundberg and his Co-worker did a study about "Identification and Quantification of Indole-3-methanol in Etiolated Seedlings of Scots Pine"(Pinus sylvestris L.). Indole-3-methanol did exist in buffer extract from etiolated seedlings of Pinus sylvestris L.And the stability of indole-3-methanol at different pH levels was investigated.
As a metabolism of indole-3-acetic acid, Indole-3-methanol can be produced by the oxidation of indole-3-acetic acid catalyzed by two cytosolic basic isoperoxidases from Lupinus. This study has been done by A. Barceló in 1990. While indole-3-methanol is only a minor product of the oxidation of indole-3-acetic acid catalyzed by extracellular acidic isoperoxidases, it is the only product of the oxidation of indole-3-acetic acid catalyzed by two cytosolic basic isoperoxidases (EC 1.11.1.7) from lupin (Lupinus albus L.) hypocotyls. It can be produced by the breakdown of the glucosinolate glucobrassicin.
Indole-3-carbinol Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LDLo | subcutaneous | 500mg/kg (500mg/kg) | BEHAVIORAL: COMA | Food and Cosmetics Toxicology. Vol. 18, Pg. 159, 1980. |
Indole-3-carbinol Safety Profile
Safty informations about Indole-3-methanol (CAS NO.700-06-1):
Hazard Codes:Xi
Risk Statements:36/38
36/38 (Irritating to the eyes and skin)
Safety Statements:26-36
26 (In case of contact with eyes,rinse immediately with plenty of water and seek medical advice)
36 (Wear suitable protective clothing)
WGK Germany:3
RTECS:NL9483000
Hazard Note:Irritant
Moderately toxic by subcutaneous route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
Indole-3-carbinol Specification
Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4oC/39oF.)
What can I do for you?
Get Best Price
