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Kanamycin B sulfate

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Name

Kanamycin B sulfate

EINECS
CAS No. 29701-07-3 Density 1.59g/cm3
Solubility Melting Point
Formula C18H37N5O10•H2O4S Boiling Point 807.7°Cat760mmHg
Molecular Weight 581.68 Flash Point 442.3°C
Transport Information Appearance
Safety Poison by intravenous route. Moderately toxic by subcutaneous, intramuscular, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx. Risk Codes
Molecular Structure Molecular Structure of 29701-07-3 (KANENDOMYCIN SULFATE			) Hazard Symbols
Synonyms

aminodeoxykanamycinsulfate;kanamycinb,sulfate(1:1)(salt);BEKANAMYCIN SULFATE;BEKANAMYCIN SULFATE SALT;KANAMYCIN B SULFATE;KANAMYCIN B SULFATE SALT

 

Kanamycin B sulfate Chemical Properties

IUPAC Name: (2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
CAS: 29701-07-3
Following is the Molecular Structure of Kanendomycin sulfate (29701-07-3):

SMILES: O(C2[C@@H](O)[C@H](O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N)[C@@H](N)C[C@H]2N)[C@H]3O[C@@H]([C@@H](O)[C@H](N)[C@H]3O)CO
InChI: InChI=1/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16?,17+,18+/m0/s1
InChIKey: SKKLOUVUUNMCJE-DNGLBLDUBA
Std.InChI: InChI=1S/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16?,17+,18+/m0/s1
Std.InChIKey: SKKLOUVUUNMCJE-DNGLBLDUSA-N
Molecular Formula: C18H39N5O14S
Molecular Weight: 581.59
Boiling Point: 807.7℃ at 760mmHg
Flash Point: 442.3℃
Molar Volume: 303.8cm3
Density: 1.59g/cm3
Molar Refractivity: 113.22cm3
Surface Tension: 101.4dyne/cm
Polarizability: 44.88 10-24cm3
Enthalpy of Vaporization: 133.71kJ/mol
Vapour Pressure: 3.43E-30mmHg at 25℃

Kanamycin B sulfate Toxicity Data With Reference

mouse LD50 intracrebral 5950ug/kg (5.95mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Chemotherapy Vol. 17, Pg. 1664, 1969.
mouse LD50 intramuscular 628mg/kg (628mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
mouse LD50 intraperitoneal 760mg/kg (760mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
mouse LD50 intravenous 112mg/kg (112mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
mouse LD50 subcutaneous 740mg/kg (740mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
rat LD50 intramuscular 1420mg/kg (1420mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
rat LD50 intraperitoneal 1400mg/kg (1400mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
rat LD50 intravenous 141mg/kg (141mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.
rat LD50 subcutaneous 1900mg/kg (1900mg/kg)   Drugs in Japan Vol. 6, Pg. 742, 1982.

Kanamycin B sulfate Safety Profile

Safety Statements: 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK: Germany 2
RTECS: WK1976500
Poison by intravenous route. Moderately toxic by subcutaneous, intramuscular, and intraperitoneal routes.

Kanamycin B sulfate Specification

 Kanendomycin sulfate (29701-07-3),which also can be called for Aminodeoxykanamycinsulfate ; Kanamycinb,sulfate(1:1)(salt) ; Bekanamycin sulfate ; Bekanamycin sulfate salt ; Kanamycin b sulfate ; Kanamycin b sulfate salt ; Aminodeoxybekanamycin .When Kanendomycin sulfate (29701-07-3) was heated, it emits toxic fumes of SOx and NOx . Kanendomycin sulfate (29701-07-3) is an Aminoglycoside Antibiotic that is the 2-Amino,2-Deoxy-analog of Kanamycin A. Mode of Action: Binds to 70S Ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasm.

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