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Ketorolac tris salt

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Name

Ketorolac tris salt

EINECS
CAS No. 74103-07-4 Density
Solubility Melting Point 160-161 °C
Formula C15H13NO3 Boiling Point 493.2 °C at 760 mmHg
Molecular Weight 376.40 Flash Point 252.1 °C
Transport Information UN 2811 6.1/PG 3 Appearance
Safety 26-45-36/37/39 Risk Codes 25-36/37/38-23/24/25
Molecular Structure Molecular Structure of 74103-07-4 (Ketorolac tris salt) Hazard Symbols ToxicT
Synonyms

Ketorolac Tromethamine;RS 37619;Ketorolac Trometamol;

 

Ketorolac tris salt Chemical Properties

Molecular Structure:

Molecular Formula: C19H24N2O6
Molecular Weight: 376.4037
IUPAC Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol; 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Synonyms of Ketorolac Tromethamine (CAS NO.74103-07-4): Ketorolac tromethamine [USAN] ; (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) ; Acular ; Acular LS ; Acular PF ; Acular preservative free ; Acuvail ; Godek ; Sprix ; Syntex ; Toradol ; Tromethamine ketorolac ; UNII-4EVE5946BQ ; 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro, (+-)-, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
CAS NO: 74103-07-4
Classification Code: Analgesic ; Analgesics ; Analgesics, non-narcotic ; Anti-Inflammatory Agents ; Anti-inflammatory agents, non-steroidal ; Antirheumatic Agents ; Cyclooxygenase inhibitors ; Drug / Therapeutic Agent ; Enzyme Inhibitors ; Human Data ; Peripheral Nervous System Agents ; Sensory System Agents
Melting point: 160-161 °C 
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 48.3 Å2
Flash Point: 252.1 °C
Enthalpy of Vaporization: 80.07 kJ/mol
Boiling Point: 493.2 °C at 760 mmHg
Vapour Pressure: 1.52E-10 mmHg at 25°C

Ketorolac tris salt Uses

 Ketorolac Tromethamine (CAS NO.74103-07-4) is a pyrrolizine carboxylic acid derivative structurally related to indomethacin. So it often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory which acts by inhibiting the bodily synthesis of prostaglandins.

Ketorolac tris salt Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intramuscular 857ug/kg (0.857mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 305, 1994.
man TDLo intramuscular 858ug/kg (0.858mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Annals of Pharmacotherpy. Vol. 26, Pg. 1237, 1992.
man TDLo intramuscular 4300ug/kg/8D- (4.3mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"
Clinical Nephrology. Vol. 44, Pg. 276, 1995.
man TDLo intramuscular 19853ug/kg/12 (19.853mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Annals of Pharmacotherpy. Vol. 27, Pg. 1055, 1993.
mouse LD50 intraperitoneal 225mg/kg (225mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA
Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.
mouse LD50 oral 293mg/kg (293mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.
rat LD50 oral 189mg/kg (189mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.
women LDLo intramuscular 15mg/kg/6D-I (15mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Archives of Internal Medicine. Vol. 153, Pg. 1000, 1993.
women TDLo intramuscular 600ug/kg (0.6mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS Archives of Internal Medicine. Vol. 158, Pg. 411, 1998.
women TDLo intramuscular 1200ug/kg (1.2mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Southern Medical Journal. Vol. 87, Pg. 282, 1994.
women TDLo intramuscular 8400ug/kg/3D- (8.4mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" American Journal of Kidney Diseases. Vol. 24, Pg. 578, 1994.

Ketorolac tris salt Safety Profile

Hazard Codes: ToxicT
Risk Statements: 36/37/38-23/24/25 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-45-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UY7759900
HazardClass: 6.1(a)
PackingGroup: II 
 Ketorolac Tromethamine (CAS NO.74103-07-4) is irritating to eyes, respiratory system and skin, when you have to contact with it you should avoid contact with skin and eyes or wear suitable protective clothing, gloves and eye/face protection. And it is toxic by inhalation, in contact with skin and if swallowed. In case of accident or if you feel unwell, seek medical advice immediately.
The side effects associated with ketorolac are, gastrointestinal ulcers, bleeding and perforation; kidney failure; hemorrhage, and hypersensitivity reactions. So it should be used by controlling.

Ketorolac tris salt Specification

 Ketorolac Tromethamine (CAS NO.74103-07-4) is not recommended for obstetric analgesia because it has not been adequately tested for obstetrical administration and has demonstrable fetal toxicity in laboratory animals. And it is not recommended for long-term chronic pain patients neither.However, Ketorolac Tromethamine has been co-administered with meperidine and morphine without apparent adverse effects on patients.

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