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| Name |
L-5-Hydroxytryptophan |
EINECS | 224-411-1 |
| CAS No. | 4350-09-8 | Density | 1.484 g/cm3 |
| Solubility | slightly soluble in water | Melting Point |
270 °C (dec.)(lit.) |
| Formula | C11H12N2O3 | Boiling Point | 520.6 °C at 760 mmHg |
| Molecular Weight | 220.23 . | Flash Point | 268.7 °C |
| Transport Information | UN 2811 6.1/PG 3 | Appearance | white to pale grey powder |
| Safety | 36-26 | Risk Codes | 22-36/37/38-65-20/21/22-20/21 |
| Molecular Structure |
|
Hazard Symbols |
 Xn,  Xi
|
| Synonyms |
Tryptophan,5-hydroxy-, L- (8CI);(S)-5-Hydroxytryptophan;5-Hydroxy-L-tryptophan;5-Hydroxyl-L-tryptophan;Cincofarm;L-5-HTP;Levothym;Levotinine;Oxitriptan;Oxyfan;Pretonine;Quietim;Serotonyl;Telesol;Tript-Oh; |
Molecular Formula: C11H12N2O3
Molecular Weight: 220.22
EINECS: 224-411-1
Flash piont: 175 °F
Refractive index: n20/D 1.4850(lit.)
Melting Point: 270 °C (dec.)(lit.)
Density: 0.902 g/mL at 25 °C(lit.)
Appearance: White to pale grey powder
Alpha: -32.5 º (c=1,H2O on dry basis)
Melting point: 270 °C (dec.)(lit.)
Storage tempreture: 2-8 °C
Water solubility: 10 mg/mL
Appearance: Colorless to pale pink crystals
Structure of L-5-Hydroxytryptophan (CAS NO.4350-09-8):
.gif)
IUPAC Name: (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
Canonical SMILES: C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
Isomeric SMILES: C1=CC2=C(C=C1O)C(=CN2)C[C@@H](C(=O)O)N
InChI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
InChIKey: LDCYZAJDBXYCGN-VIFPVBQESA-N
Product Category of L-5-Hydroxytryptophan (CAS NO.4350-09-8): Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Biochemicals Found in Plants;Nutrition Research;Tryptophan Derivatives;Unnatural Amino Acid Derivatives
L-5-Hydroxytryptophan (CAS NO.4350-09-8) is used as an antidepressant, appetite suppressant, and sleep aid.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 298mg/kg (298mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975. |
| mouse | LD50 | intravenous | 375mg/kg (375mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973. |
| mouse | LD50 | oral | 1708mg/kg (1708mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975. |
| mouse | LD50 | subcutaneous | 418mg/kg (418mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975. |
| rabbit | LD50 | oral | 285mg/kg (285mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975. |
| rat | LD50 | intraperitoneal | 91mg/kg (91mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973. |
| rat | LD50 | intravenous | 27mg/kg (27mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975. |
| rat | LD50 | oral | 243mg/kg (243mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973. |
| rat | LD50 | subcutaneous | 149mg/kg (149mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975. |
Safety Information of L-5-Hydroxytryptophan (CAS NO.4350-09-8):
Hazard Codes: Xn
Xi
Risk Statements: 22-36/37/38-65-20/21/22-20/21
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R65: Harmful: may cause lung damage if swallowed.
R20/21: Harmful by inhalation and in contact with skin.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36-26
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YN7110000
HazardClass: 6.1
PackingGroup: III
HS Code: 29339990
L-5-Hydroxytryptophan , its cas register number is 4350-09-8. It also can be called 5-Hydroxy-L-tryptophan ; Oxitriptan ; Tript-OH ; and L-Tryptophan, 5-hydroxy- . L-5-Hydroxytryptophan (CAS NO. 4350-09-8) is a naturally occurring amino acid, and is a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. It is marketed in the United States and other countries as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. However, according to a 2001 meta-analysis, no sufficient high quality research has been done to establish its effectiveness for treatment of clinical depression or dysthymia.
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