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Name |
L-Epinephrine hydrochloride |
EINECS | 200-230-3 |
CAS No. | 55-31-2 | Density | N/A |
PSA | 72.72000 | LogP | 1.54350 |
Solubility | N/A | Melting Point |
157 °C |
Formula | C9H14ClNO3 | Boiling Point | 413.1 °C at 760 mmHg |
Molecular Weight | 219.668 | Flash Point | 207.9 °C |
Transport Information | N/A | Appearance | crystals |
Safety | Risk Codes | R24/25; R36/37/38 | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
1,2-Benzenediol,4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride (9CI);1,2-Benzenediol,4-[1-hydroxy-2-(methylamino)ethyl]-, hydrochloride, (R)-;Benzyl alcohol,3,4-dihydroxy-a-[(methylamino)methyl]-,hydrochloride, (-)- (8CI);(-)-Adrenaline hydrochloride;(-)-Epinephrinehydrochloride;Adrenalin chloride;Adrenalin hydrochloride;Adrenalinechlorhydrate;Adrenaline chloride;Adrenaline hydrochloride;Epinephrinechloride;Epinephrine hydrochloride;Gelatin-Epinephrine;Glaucon;SupranephrinSolution;Suprarenin hydrochloride;Tonogen;l-Adrenaline chloride;l-Adrenalinehydrochloride;l-Epinephrine chloride;l-Methylaminoethanolcatechol hydrochloride; |
Article Data | 1 |
Conditions | Yield |
---|---|
In d(4)-methanol; water-d2 Equilibrium constant; |
IUPAC Name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol hydrochloride
Synonyms of L-Epinephrine hydrochloride (CAS NO.55-31-2): (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride ; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol hydrochloride ; Adrenalin chloride ; Epinephrine chloride ; l-Methylaminoethanolcathechol hydrochloride
CAS NO: 55-31-2
Molecular Formula: C9H14ClNO3
Molecular Weight: 219.67
Molecular Structure:
EINECS: 200-230-3
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 6
Polar Surface Area: 30.93 Å2
Flash Point: 207.9 °C
Melting Poin: 157°C
Boiling Point: 413.1 °C at 760 mmHg
Enthalpy of Vaporization: 70.21 kJ/mol
Vapour Pressure: 1.45E-07 mmHg at 25°C
Appearance: crystals
SMILES: Cl.Oc1ccc(cc1O)[C@@H](O)CNC
InChI: InChI=1/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H/t9-;/m0./s1
InChIKey: ATADHKWKHYVBTJ-FVGYRXGTBN
Std. InChI: InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H/t9-;/m0./s1
Std. InChIKey: ATADHKWKHYVBTJ-FVGYRXGTSA-N
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | intravenous | 200ug/kg (0.2mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963. | |
guinea pig | LDLo | subcutaneous | 2mg/kg (2mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963. | |
mouse | LD50 | intraperitoneal | 4664ug/kg (4.664mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 110, 1947. |
mouse | LD50 | intravenous | 140ug/kg (0.14mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA | European Journal of Pharmacology. Vol. 9, Pg. 289, 1970. |
mouse | LD50 | subcutaneous | 1980ug/kg (1.98mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946. |
mouse | LDLo | oral | 50mg/kg (50mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963. | |
rat | LD50 | intraduodenal | 35mg/kg (35mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | oral | 24mg/kg (24mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LD50 | subcutaneous | 5mg/kg (5mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
rat | LDLo | intravenous | 50ug/kg (0.05mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925. |
Reported in NTP Carcinogenesis Studies (Inhalation); Inadequate Study: rat, mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-380 ,1990. .
Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also VASOTONIN and other adrenalin compounds.
Safety Information aboout L-Epinephrine hydrochloride (CAS NO.55-31-2):
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II
Health Hazard of L-Epinephrine hydrochloride (CAS NO.55-31-2): Adverse reactions include restlessness; anxiety; headache; tremor; weakness; dizziness; pallor; respiratory difficulties; palpitation; nausea and vomiting.