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L-Glutamine

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Name

L-Glutamine

EINECS 200-292-1
CAS No. 56-85-9 Density 1.321 g/cm3
Solubility water: 25 mg/mL Melting Point 185 °C (dec.)(lit.)
Formula C5H10N2O3 Boiling Point 445.6 °C at 760 mmHg
Molecular Weight 146.17 Flash Point 223.3 °C
Transport Information Appearance White crystalline powder
Safety 26-24/25-36/37/39-27 Risk Codes 36-36/37/38
Molecular Structure Molecular Structure of 56-85-9 (L-Glutamine) Hazard Symbols IrritantXi
Synonyms

(S)-2,5-Diamino-5-oxopentanoic acid;Glutamine (VAN);L-Glutamid;Glutamine (USP);(2S)-2-amino-4-carbamoylbutanoic acid;(2S)-2-amino-4-carbamoyl-butanoic acid;L-2-Aminoglutaramic acid;Pentanoic acid, 2,5-diamino-5-oxo-, (S)-;Glutamine [USAN];(2S)-2-azaniumyl-4-carbamoyl-butanoate;Levoglutamina;Cebrogen;Levoglutamidum [INN-Latin];L-(+)-Glutamine;Glumin (amino acid);Levoglutamid;Miglu-P;Levoglutamide [DCF:INN];L-Glutamic acid .gamma.-amide;2-Aminoglutaramic acid;Levoglutamida [INN-Spanish];L-Glutamic acid gamma-amide;Levoglutamide;Glavamin;Glutamic acid 5-amide;(2S)-2,5-diamino-5-oxopentanoic acid;Glutamic acid amide;2,5-Diamino-5-oxopentanoic acid, (S)-;L(+)-Glutamine;L(+)-Glutamic acid-5-amide;H-Gln-OH;Glutamine (P347);Glutamine;L-Glutamine FCC5;L-Gln-OH;L-Glutamine;L-Glutamine FCC4;L-2-Aminoglutaramidic acid;2-Aminoglutaramic acid, L-;L-Glutamic acid 5-amide;2-amino-4-carbamoyl-butanoic acid;

 

L-Glutamine Consensus Reports

  L-Glutamine (CAS NO.77668-42-9) is reported in EPA TSCA Inventory.

L-Glutamine Specification

L-Glutamine, with the IUPAC Name of (2S)-2,5-Diamino-5-oxopentanoic acid, is one kind of white crystalline powder. And its Classification Code are including Dietary supplement; Drug / Therapeutic Agent; Human Data; Mutation data. L-Glutamine(CAS NO.56-85-9) is the most abundant amino acid (building block of protein) in the body. The popular amino acid L-Glutamine is found in protein powders, beans, meats, fish, poultry, dairy products, and of course. It is used in the gut and immune system to maintain optimal performance. 60% of free-form amino acids floating in skeletal muscles is L-Glutamine.

Physical properties about L-Glutamine are: (1)ACD/LogP: -1.576; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -4.08; (4)ACD/LogD (pH 7.4): -4.08; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.524; (13)Molar Refractivity: 33.837 cm3; (14)Molar Volume: 110.546 cm3; (15)Polarizability: 13.414 10-24cm3; (16)Surface Tension: 64.588996887207 dyne/cm; (17)Density: 1.322 g/cm3; (18)Flash Point: 223.272 °C; (19)Enthalpy of Vaporization: 77.128 kJ/mol; (20)Boiling Point: 445.568 °C at 760 mmHg

Uses of L-Glutamine:
1). L-Glutamine (CAS NO.77668-42-9) has been studied extensively over the past 10–15 years and has been shown to be useful in treatment of serious illnesses, injury, trauma, burns, cancer and its treatment related side-effects as well as in wound healing for postoperative patients.
2). Glutamine is also marketed as a supplement used for muscle growth in weightlifting, bodybuilding, endurance, and other sports.
3). Glutamine has also been taken to enhance brain function as it fuels two of the brain's most important neurotransmitters.
4). It has also been used in the treatment of ADHD, anxiety,and depression.
5). It has also been used in recovery programs to break sugar craving cycles in alcoholics and assist diabetics in the management of sugar cravings.
6). It is also used as an anti-inflammatory in the treatment of autoimmune diseases and preserves Glutathione levels in the liver.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1;
(2)InChIKey=ZDXPYRJPNDTMRX-VKHMYHEASA-N;
(3)SmilesC([C@@H](C(=O)O)N)CC(N)=O

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 27mg/kg/1W-I (27mg/kg) BEHAVIORAL: EUPHORIA American Journal of Psychiatry. Vol. 141, Pg. 1302, 1984.
mouse LD50 oral 21700mg/kg (21700mg/kg)   Drugs in Japan Vol. 6, Pg. 228, 1982.
rat LD50 oral 7500mg/kg (7500mg/kg)   Drugs in Japan Vol. 6, Pg. 228, 1982.

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