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Name |
L-alpha-Methyltyrosine |
EINECS | 211-599-5 |
CAS No. | 672-87-7 | Density | 1.283g/cm3 |
PSA | 83.55000 | LogP | 1.43700 |
Solubility | N/A | Melting Point |
320-340°C dec. |
Formula | C10H13 N O3 | Boiling Point | 383.7oC at 760 mmHg |
Molecular Weight | 195.218 | Flash Point | 185.9oC |
Transport Information | N/A | Appearance | White Solid |
Safety | 2368400 | Risk Codes | 2368400 |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
Tyrosine,a-methyl-, L- (8CI);(S)-2-(4-Hydroxybenzyl)-2-aminopropanoic acid; (S)-a-Methyltyrosine; Demser; L(-)-Metyrosine;L-Metyrosine; L-a-MT;L-a-Methyl-p-tyrosine; L-a-Methyltyrosine; MK 781;Metirosine; Metyrosine; a-Methyl-L-tyrosine |
Article Data | 7 |
(2S)-2-amino-3-(4-methoxyphenyl)-2-methyl-propionamide hydrogen bromide salt
L-methyltyrosine
Conditions | Yield |
---|---|
With water; hydrogen bromide at 105℃; for 17h; Product distribution / selectivity; | 86% |
2-(S)-amino-3-(4-methoxyphenyl)-2-methylpropionamide
L-methyltyrosine
Conditions | Yield |
---|---|
With water; hydrogen bromide at 120℃; for 5h; Product distribution / selectivity; | 84% |
Multi-step reaction with 2 steps 1: water; hydrogen bromide / methanol / 100 °C / 15 - 22.5 Torr 2: water; hydrogen bromide / 17 h / 105 °C View Scheme |
(2S)-2-amino-3-(4-methoxyphenyl)-2-methyl-propionamide hydrochloride
L-methyltyrosine
Conditions | Yield |
---|---|
With hydrogen bromide In water at 120℃; for 4h; Product distribution / selectivity; | 83% |
(2S)-2-amino-3-(4-methoxyphenyl)-2-methylpropionamide formic acid salt
L-methyltyrosine
Conditions | Yield |
---|---|
With water; hydrogen bromide at 105℃; for 17h; Product distribution / selectivity; | 82% |
L-methyltyrosine
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 100℃; for 4h; | 75.4% |
L-methyltyrosine
Conditions | Yield |
---|---|
Stage #1: tert-butyl (2R)-2-amino-3-(4-methoxyphenyl)-2-methylpropanoate With boron tribromide In dichloromethane at 20℃; for 1.5h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity; | 45.4% |
N-Chloroacetyl-α-methyltyrosine
A
L-methyltyrosine
B
α-methyl-D-tyrosine
C
N-Chloroacetyl-D-α-methyltyrosine
D
N-Chloroacetyl-L-α-methyltyrosine
Conditions | Yield |
---|---|
With potassium hydroxide; porcine kidney acylase I pH 7.5-8.0; Yields of byproduct given; | A 30% B n/a C n/a D n/a |
With potassium hydroxide; porcine kidney acylase I pH 7.5-8.0; Yields of byproduct given; | A n/a B 30% C n/a D n/a |
With potassium hydroxide; porcine kidney acylase I pH 7.5-8.0; Yield given. Yields of byproduct given; |
α-methyl-β-p-methoxyphenyl-alanine
L-methyltyrosine
Conditions | Yield |
---|---|
With hydrogen bromide |
N-Chloroacetyl-α-methyltyrosine
A
L-methyltyrosine
B
N-Chloroacetyl-D-α-methyltyrosine
Conditions | Yield |
---|---|
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2; |
2-Nitro-2-(4-hydroxybenzyl)propionsaeureethylester
L-methyltyrosine
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide; nickel 1.) MeOH, reflux, 1 h, 2.) MeOH, 28 h; Yield given. Multistep reaction; |
Molecule structure of L-Tyrosine, a-methyl- (CAS NO.672-87-7):
IUPAC Name: (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
Molecular Weight: 195.21512 [g/mol]
Molecular Formula: C10H13NO3
Index of Refraction: 1.599
Molar Refractivity: 52.01 cm3
Molar Volume: 152 cm3
Surface Tension: 60.6 dyne/cm
Density: 1.283 g/cm3
Melting Point: 320-340 °C
Storage temp.: −20 °C
Flash Point: 185.9 °C
Enthalpy of Vaporization: 66.7 kJ/mol
Boiling Point: 383.7 °C at 760 mmHg
Vapour Pressure: 1.42E-06 mmHg at 25 °C
XLogP3-AA: -1.6
H-Bond Donor: 3
H-Bond Acceptor: 4
Rotatable Bond Count: 3
Tautomer Count: 2
Exact Mass: 195.089543
MonoIsotopic Mass: 195.089543
Topological Polar Surface Area: 83.6
Heavy Atom Count: 14
Canonical SMILES: CC(CC1=CC=C(C=C1)O)(C(=O)O)N
Isomeric SMILES: C[C@](CC1=CC=C(C=C1)O)(C(=O)O)N
InChI: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChIKey: NHTGHBARYWONDQ-JTQLQIEISA-N
EINECS: 211-599-5
Product Categories of L-Tyrosine, a-methyl- (CAS NO.672-87-7): Amino acids methyl、ethyl、t-butyl series;Amino Acids & Derivatives
L-Tyrosine, a-methyl- (CAS NO.672-87-7) is a tyrosine hydroxylase inhibitor. It is also an antihypertensive in pheochromocytoma.
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
L-Tyrosine, a-methyl- (CAS NO.672-87-7) is also called Alpha-Methyltyrosine ; Metyrosine [USAN] ;
(-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure ; (-)-alpha-Methyl-L-tyrosine (S)-alpha-Methyltyrosine ; Demser ; L-alpha-Methyltyrosine ; Metirosina ; Metirosina [INN-Spanish] ; Metirosinum ; Metirosinum [INN-Latin] ; Metyrosine ; L-Tyrosine, alpha-methyl-, (-)- ; Metirosine . It is white Solid.