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Name	Lanosta-8,24-dien-3-ol,(3beta)-	EINECS	201-214-9
CAS No.	79-63-0	Density	0.988 g/cm³
PSA	20.23000	LogP	8.47910
Solubility	N/A	Melting Point	137 °C
Formula	C₃₀H₅₀O	Boiling Point	498.855 °C at 760 mmHg
Molecular Weight	426.726	Flash Point	221.143 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Lanosta-8,24-dien-3b-ol (8CI);Lanostadien-3b-ol (7CI);Lanosterol (6CI);3b-Hydroxylanosta-8,24-diene;4,4,14a-Trimethylcholesta-8,24-dien-3b-ol;5a-Lanosta-8,24-dien-3b-ol;Lanosta-8,24-dienol;Lanosterin;Lanster;NSC60677;	Article Data	25

Lanosta-8,24-dien-3-ol,(3beta)- Synthetic route

: 2671-68-3
O-acetyl-lanosterol

: 79-63-0
tirucallol

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol for 72h; Ambient temperature;	94%
With potassium hydroxide In ethanol at 60℃; for 2h;
Multi-step reaction with 3 steps 1: SeO2 / aq. ethanol 2: NaBH4 / aq. ethanol 3: (i) SO3, Py, THF, (ii) LiAlH4 View Scheme

: 14050-42-1, 54910-48-4, 54910-49-5, 54910-50-8, 55058-26-9, 55058-27-0, 132199-42-9, 138809-21-9, 147731-51-9, 7200-26-2
2,3-Oxidosqualene

: 79-63-0
tirucallol

Conditions

Conditions	Yield
With Trypanosoma cruzi LHY4-[pBJ1.22] transformant at 25℃; for 24h;	82%
With K-phosphate buffer; Triton X-100 In water at 37℃; for 5h; oxidosqualene-lanosterol cyclase; effect of various detergents;
With Trypanosoma cruzi oxidosqualene cyclase; 3-(trimethylsilyl)-1-propanesulfonic acid,sodium salt In dimethylsulfoxide-d6; aq. phosphate buffer at 37℃; pH=7; Reagent/catalyst; Enzymatic reaction;

: 14050-42-1, 54910-48-4, 54910-49-5, 54910-50-8, 55058-26-9, 55058-27-0, 132199-42-9, 138809-21-9, 147731-51-9, 7200-26-2
2,3-Oxidosqualene

A: 514-45-4
parkeol

B: 79-63-0
tirucallol

C: 69637-82-7
Lanost-24-ene-3β,9α-diol

Conditions

Conditions	Yield
With S. cerevisiae lanosterol-synthase Thr 384 Tyr mutant Product distribution; Further Variations:; Reagents;	A 11% B 79% C 10%

: 124770-75-8
Octanoic acid (3S,5R,10S,13R,14R,17R)-17-((R)-1,5-dimethyl-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

: 79-63-0
tirucallol

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol; benzene for 240h; Ambient temperature;	19%

: 57-88-5
cholesterol

: 79-63-0
tirucallol

Conditions

Conditions	Yield
ueber mehrere Stufen;

: 469-38-5
cycloartenol

A: 514-45-4
parkeol

B: 79-63-0
tirucallol

C: 110654-88-1
Cucurbita-5(10),24-dien-3β-ol

D: 23515-91-5
tirucalla-7,24-dien-3β-ol

Conditions

Conditions	Yield
With sulfuric acid In isopropyl alcohol at 80℃; for 12h; Further byproducts given;

: 20905-52-6
3β-acetoxy-24ξ-hydroxylanost-8-ene

A: 79-62-9, 564-60-3, 6198-06-7, 6593-55-1, 13879-09-9, 39701-94-5, 59684-64-9, 78821-82-6
24,25-dihydrolanosterol

B: 79-63-0
tirucallol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; trichlorophosphate 1.) pyridine, 5 h, reflux, 2.) dioxane, 10 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;

: 68612-46-4
3β-acetoxy-(24E)-lanostadiene-8,24 ol-26

: 79-63-0
tirucallol

Conditions

Conditions	Yield
(i) SO3, Py, THF, (ii) LiAlH4; Multistep reaction;

: 14050-42-1, 54910-48-4, 54910-49-5, 54910-50-8, 55058-26-9, 55058-27-0, 132199-42-9, 138809-21-9, 147731-51-9, 7200-26-2
2,3-Oxidosqualene

A: 514-45-4
parkeol

B: 469-38-5
cycloartenol

C: 79-63-0
tirucallol

Conditions

Conditions	Yield
With CAS1Ile841Val mutant; YPG+heme rearrangement; cyclization;

: 469-38-5
cycloartenol

A: 514-45-4
parkeol

B: 79-63-0
tirucallol

C: 110654-88-1
Cucurbita-5(10),24-dien-3β-ol

D: 35012-08-9
10α-cucurbita-5,24-diene-3β-ol

E: 23515-91-5
tirucalla-7,24-dien-3β-ol

F: 129763-89-9
5α-Lanosta-9(11),25-dien-3β-ol

G other alcohols, and dehydration products: other alcohols, and dehydration products

Conditions

Conditions	Yield
With sulfuric acid In isopropyl alcohol at 80℃; for 12h; Product distribution;

...Expand

Lanosta-8,24-dien-3-ol,(3beta)- Specification

The Lanosta-8,24-dien-3-ol,(3beta)- is an organic compound with the formula C₃₀H₅₀O. The IUPAC name of this chemical is (3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol. With the CAS registry number 79-63-0, it is also named as (3β)-Lanosta-8,24-dien-3-ol. The product's categories are Miscellaneous Natural Products; Organics; Biochemistry; Hydroxysteroids; Steroids. Besides, it should be stored in a closed and cool place. It is used for atherosclerosis research.

Physical properties about Lanosta-8,24-dien-3-ol,(3beta)- are: (1)ACD/LogP: 10.52; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 10.521; (4)ACD/LogD (pH 7.4): 10.521; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 10000000; (8)ACD/KOC (pH 7.4): 10000000; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 20.23 Å²; (13)Index of Refraction: 1.53; (14)Molar Refractivity: 133.401 cm³; (15)Molar Volume: 431.845 cm³; (16)Polarizability: 52.884×10^-24cm³; (17)Surface Tension: 37.965 dyne/cm; (18)Density: 0.988 g/cm³; (19)Flash Point: 221.143 °C; (20)Enthalpy of Vaporization: 88.348 kJ/mol; (21)Boiling Point: 498.855 °C at 760 mmHg.

Uses of Lanosta-8,24-dien-3-ol,(3beta)-: it can be used to produce (5a)-euph-8-en-3b-ol at ambient temperature. It will need reagent H₂, catalyst Pd/C (10 percent) and solvent ethanol with reaction time of 4 hours. The yield is about 85%.

You can still convert the following datas into molecular structure:
(1)SMILES: C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C
(2)InChI:InChI=1/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1
(3)InChIKey: CAHGCLMLTWQZNJ-BQNIITSRBP
(4)Std. InChI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1
(5)Std. InChIKey: CAHGCLMLTWQZNJ-BQNIITSRSA-N

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