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Cas Database |
| Name |
Lofexidine hydrochloride |
EINECS | N/A |
| CAS No. | 21498-08-8 | Density | g/cm3 |
| PSA | 33.62000 | LogP | 3.32880 |
| Solubility | N/A | Melting Point |
230-232°C |
| Formula | C11H12 Cl2 N2 O . Cl H | Boiling Point | 421.5 °C at 760 mmHg |
| Molecular Weight | 295.596 | Flash Point | 208.7 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion and intravenous routes. An experimental teratogen. Experimental reproductive effects. An antihypertensive agent. When heated to decomposition it emits toxic fumes of NOx and HCl. | Risk Codes | 25 |
| Molecular Structure |
|
Hazard Symbols | T |
| Synonyms |
1H-Imidazole,2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-, monohydrochloride (9CI);2-Imidazoline, 2-[1-(2,6-dichlorophenoxy)ethyl]-, monohydrochloride (8CI); Baq168; Britlofex; Lofetensin; Lofexidine hydrochloride; Loxacor; MDL 14042 |
Article Data | 4 |
Lofexidine hydrochloride Chemical Properties
Product Name: Lofexidine hydrochloride (CAS NO.21498-08-8)
Molecular Formula: C11H13Cl3N2O
Molecular Weight: 295.59g/mol
Mol File: 21498-08-8.mol
Appearance: Crystalline Solid
Melting Point: 230-232°C
Boiling point: 421.5 °C at 760 mmHg
Flash Point: 208.7 °C
Enthalpy of Vaporization: 64.94 kJ/mol
Vapour Pressure: 6.35E-07 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 3
Product Categories: Active Pharmaceutical Ingredients; Aromatics;Heterocycles; Intermediates and Fine Chemicals; Pharmaceuticals
Lofexidine hydrochloride Uses
a2-Adrenoceptor agonist related structurally to Clonidine. Lofexidine hydrochloride (CAS NO.21498-08-8) is used in treatment of opioid withdrawal symptoms; antihypertensive.
Lofexidine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 8mg/kg (8mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982. |
| dog | LD50 | oral | 70mg/kg (70mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982. |
| human | TDLo | oral | 270ug/kg/6W-I (0.27mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 976, 1982. |
| mouse | LD50 | intravenous | 8mg/kg (8mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982. |
| mouse | LD50 | oral | 54mg/kg (54mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 966, 1982. | |
| rat | LD50 | intravenous | 8mg/kg (8mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982. |
| rat | LD50 | oral | 70mg/kg (70mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 955, 1982. |
Lofexidine hydrochloride Safety Profile
Poison by ingestion and intravenous routes. An experimental teratogen. Experimental reproductive effects. An antihypertensive agent. When heated to decomposition it emits toxic fumes of NOx and HCl.
Lofexidine hydrochloride Specification
Lofexidine hydrochloride ,its CAS NO. is 21498-08-8,the synonyms is Lofetensin,loxacor ; Lofexidine hcl ; Lofexidine, hydrochloride ; Mdl-14042a ; Ba-168 ; Britlofex ; 2-[1-(2,6-Dichlorophenoxy)ethyl]-2-imidazoline hydrochloride ; 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1h-imidazole hydrochloride .
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