Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Meclofenoxate hydrochloride |
EINECS | 222-975-3 |
CAS No. | 3685-84-5 | Density | 1.3255 (rough estimate) |
PSA | 38.77000 | LogP | 2.62560 |
Solubility | N/A | Melting Point |
133-135 °C |
Formula | C12H17Cl2NO3 | Boiling Point | 345.9 °C at 760 mmHg |
Molecular Weight | 294.178 | Flash Point | 163 °C |
Transport Information | N/A | Appearance | white crystal powder |
Safety | 26-36 | Risk Codes | 22-36/37/38 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
Aceticacid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (9CI);Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester hydrochloride(6CI,8CI);2-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride;Acetic acid,2-(4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (1:1);Acephen;Brenal;Cellative;Centrophenoxine;Centrophenoxinehydrochloride;Cerutil;Dimethylaminoethyl 4-chlorophenoxyacetatehydrochloride;Dimethylaminoethyl p-chlorophenoxyacetate hydrochloride;Helfergin;Lucidril;Lucidryl hydrochloride;Marucotol;Methocynal;Proserout; |
Article Data | 4 |
2-(N,N-dimethylamino)ethanol
4-chlorophenyloxyacetyl chloride
meclofenoxate hydrochloride
Conditions | Yield |
---|---|
In chloroform | 90% |
With benzene Behandeln des Reaktionsprodukts mit Chlorwasserstoff in Aether und Aceton; | |
Stage #1: 2-(N,N-dimethylamino)ethanol; 4-chlorophenyloxyacetyl chloride In dichloromethane at 20℃; Green chemistry; Stage #2: With hydrogenchloride In ethyl acetate Solvent; Green chemistry; | 68 g |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: SOCl2 2: benzene / Behandeln des Reaktionsprodukts mit Chlorwasserstoff in Aether und Aceton View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / 2 h / 75 °C 2: chloroform View Scheme |
Conditions | Yield |
---|---|
With triethylamine In chloroform | 78% |
meclofenoxate hydrochloride
A
2-(N,N-dimethylamino)ethanol
B
4-Chlorophenoxyacetic acid
Conditions | Yield |
---|---|
With water In various solvent(s) at 25℃; for 8h; Rate constant; pH=5.5; effect of pH, buffer and human serum albumin concentration on hydrolysis; | |
With water Product distribution; Ambient temperature; in gastric medium; other medium; |
meclofenoxate hydrochloride
A
4-Chlorophenoxyacetic acid
B
2-(N,N-dimethylamino)ethanol hydrochloride
Conditions | Yield |
---|---|
With water at 60℃; for 120h; Kinetics; educt as different commercial film coated tablets; var. temp.s, relative humidities, additives and reaction times; | |
With buffered to pH 3.9; water at 30℃; Rate constant; in the presence and absence of sodium bisulfite (SBS); | |
With water at 80℃; under 50 Torr; Rate constant; Kinetics; Mechanism; variation of humidity, temperature and pressure; |
meclofenoxate hydrochloride
Conditions | Yield |
---|---|
With potassium permanganate; sodium hydroxide In water at 25 - 30℃; |
meclofenoxate hydrochloride
Conditions | Yield |
---|---|
In water for 0.133333h; pH=2.6; |
meclofenoxate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / chloroform 2: acetone / 24 h / 55 °C View Scheme |
meclofenoxate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / chloroform 2: acetone / 24 h / 55 °C 3: sodium hydroxide / water / Heating View Scheme |
meclofenoxate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / chloroform 2: acetone / 24 h / 55 °C 3: sodium hydroxide / water / Heating View Scheme |
Structure of Acefen (CAS NO.3685-84-5):
IUPAC Name: 2-dimethylaminoethyl 2-(4-chlorophenoxy)acetate hydrochloride
Empirical Formula: C12H17Cl2NO3
Molecular Weight: 294.1743
EINECS: 222-975-3
Flash Point: 163 °C
Enthalpy of Vaporization: 59.01 kJ/mol
Melting Point: 133-135°C
Boiling Point: 345.9 °C at 760 mmHg
Vapour Pressure: 5.95E-05 mmHg at 25°C
Synonyms of Acefen (CAS NO.3685-84-5): (p-Chlorophenoxy)acetic acid 2-(dimethylamino)ethyl ester hydrochloride ;
Acephen ; Amipolen ; Centrofenoxin ; Centrophenoxine ; Centrophenoxine hydrochloride ; Dimethylaminoethyl 4-chlorophenoxyacetate hydrochloride ; Helfergin ; Meclofenoxate HCl ; Meclofenoxate hydrochloride ; Methoxynal ;
Proserout ; p-Chlorphenoxyessigsaeure-beta-dimethylaminoaethylesters .
1. | orl-rat LD50:865 mg/kg | KSKZAN Khimiya v Sel’skom Khozyaistve. Chemistry in Agriculture. 16 (2)(1978),59. | ||
2. | ipr-mus LD50:660 mg/kg | NIIRDN Drugs in Japan. Ethical Drugs. 6 (1982),814. | ||
3. | scu-mus LD50:1560 mg/kg | NIIRDN Drugs in Japan. Ethical Drugs. 6 (1982),814. | ||
4. | orl-mus LD50:1750 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 153 (1959),1914. | ||
5. | ipr-mus LD50:845 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 153 (1959),1914. | ||
6. | ivn-mus LD50:350 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 153 (1959),1914. | ||
7. | ivn-rbt LDLo:150 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 153 (1959),1914. |
Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RTECS: AG0440000
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and HCl.