- Medazepam
- Medazepam hydrochloride
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| Name |
Medazepam hydrochloride |
EINECS | N/A |
| CAS No. | 2898-11-5 | Density | 1.18g/cm3 |
| PSA | 15.60000 | LogP | 3.92980 |
| Solubility | N/A | Melting Point |
259-260 °C |
| Formula | C16H15 Cl N2 . Cl H | Boiling Point | 404.4°Cat760mmHg |
| Molecular Weight | 307.24 | Flash Point | 198.4°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1H-1,4-Benzodiazepine,7-chloro-2,3-dihydro-1-methyl-5-phenyl-, monohydrochloride (8CI,9CI);7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine hydrochloride;Ansius; Diepin; Elbrus; Esmail; Medazepam hydrochloride; Medazepol; Megasedan;Mezepan; RB 252; Ro 5-4556; S 804 |
Medazepam hydrochloride Chemical Properties
Molecular Structure of Medazepam hydrochloride (CAS NO.2898-11-5):
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IUPAC Name: 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine hydrochloride
Empirical Formula: C16H15ClN2
Molecular Weight: 270.7567
Index of Refraction: 1.617
Surface Tension: 42.2 dyne/cm
Density: 1.18 g/cm3
Flash Point: 198.4 °C
Enthalpy of Vaporization: 65.58 kJ/mol
Boiling Point: 404.4 °C at 760 mmHg
Vapour Pressure: 9.49E-07 mmHg at 25°C
Synonyms of Medazepam hydrochloride (CAS NO.2898-11-5): 7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-benzo-1,4-diazepine monohydrochloride ; 1H-1,4-Benzodiazepine, 7-chloro-2,3-dihydro-1-methyl-5-phenyl-, monohydrochloride ; Diepin ; Medazepam HCl ; Medazepam hydrochloride ; Ro 5-4556
Medazepam hydrochloride Toxicity Data With Reference
| 1. | orl-rat LD50:900 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185. | ||
| 2. | ipr-rat LD50:210 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 18 (1968),1542. | ||
| 3. | scu-rat LD50:1700 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 18 (1968),1542. | ||
| 4. | ivn-rat LD50:91 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),833. | ||
| 5. | orl-mus LD50:710 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 18 (1968),1542. | ||
| 6. | ipr-mus LD50:314 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),833. | ||
| 7. | scu-mus LD50:720 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 18 (1968),1542. | ||
| 8. | ivn-mus LD50:47 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),833. | ||
| 9. | orl-rbt LD50:530 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 18 (1968),1542. |
Medazepam hydrochloride Consensus Reports
Medazepam hydrochloride (CAS NO.2898-11-5) was reported in KSRNAM Kiso to Rinsho. Clinical Report.
Medazepam hydrochloride Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx.