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Cas Database |
| Name |
Methyl 2-chloro-2-propenate |
EINECS | N/A |
| CAS No. | 80-63-7 | Density | 1.189 |
| PSA | 26.30000 | LogP | 0.91190 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C4H5 Cl O2 | Boiling Point | 52 °C (50 mmHg) |
| Molecular Weight | 120.535 | Flash Point | 33 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by inhalation. Human systemic effects by inhalation: conjunctiva irritation. A severe skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl−. See also ESTERS. | Risk Codes | R34; R26; R24/25; R10 |
| Molecular Structure |
|
Hazard Symbols |
 T+
|
| Synonyms |
Acrylicacid, 2-chloro-, methyl ester (6CI,7CI,8CI); 2-Chloroacrylic acid methyl ester;Methyl 2-chloro-2-propenoate; Methyl 2-chloroacrylate; Methyl2-chloropropenoate; Methyl a-chloroacrylate; NSC 32608 |
Article Data | 43 |
Methyl 2-chloro-2-propenate Synthetic route
- 89019-24-9, 108392-47-8, 108392-49-0, 113085-27-1, 113158-29-5
endo-5-Carbomethoxy-6-chloro-1,6-diazabicyclo<3.1.0>hexane
A
- 80-63-7
methyl 2-chloroacrylate
B
- 74-85-1
ethene
| Conditions | Yield |
|---|---|
| In chloroform-d1 at 80℃; for 10h; Product distribution; | A 95% B n/a |
- 89019-24-9, 108392-47-8, 108392-49-0, 113085-27-1, 113158-29-5
exo-6-chloro-5-methoxycarbonyl-1,6-diazabicyclo<3.1.0>hexane
A
- 80-63-7
methyl 2-chloroacrylate
B
- 74-85-1
ethene
| Conditions | Yield |
|---|---|
| In dichloromethane at 80℃; for 10h; | A 95% B n/a C n/a |
- 3674-09-7, 132854-28-5
methyl 2,3-dichloropropionate
- 80-63-7
methyl 2-chloroacrylate
| Conditions | Yield |
|---|---|
| In water; dimethyl sulfoxide at 120℃; for 6h; | 91% |
| With 10H-phenothiazine; tetrabutylammomium bromide; sodium hydrogencarbonate In dichloromethane; water for 1.5h; Dehydrochlorination; Heating; | 66% |
| beim Erhitzen mit protonierten Kationenaustauschern; |
- 80-63-7
methyl 2-chloroacrylate
| Conditions | Yield |
|---|---|
| With sulfuric acid In methanol | 74% |
| Conditions | Yield |
|---|---|
| Stage #1: methyl chloroacetate With Dimethyl oxalate; sodium methylate In dimethyl sulfoxide at 15 - 25℃; for 1h; Inert atmosphere; Stage #2: formaldehyd With 2,6-di-tert-butyl-4-methyl-phenol In dimethyl sulfoxide at 20 - 25℃; for 1h; Inert atmosphere; | 58.1% |
- 166666-36-0
methyl-α-bromo-α-chloro-propanoate
- 80-63-7
methyl 2-chloroacrylate
| Conditions | Yield |
|---|---|
| With lithium carbonate; lithium bromide In N,N-dimethyl-formamide at 70℃; for 24h; | 29% |
- 77825-46-8
dichloro-methylsulfanyl-acetic acid methyl ester
- 80-63-7
methyl 2-chloroacrylate
| Conditions | Yield |
|---|---|
| In tetrachloromethane at 490℃; Yield given; |
- 89019-24-9, 108392-47-8, 108392-49-0, 113085-27-1, 113158-29-5
exo-6-chloro-5-methoxycarbonyl-1,6-diazabicyclo<3.1.0>hexane
A
- 80-63-7
methyl 2-chloroacrylate
B
- 74-85-1
ethene
| Conditions | Yield |
|---|---|
| In chloroform-d1 at 40℃; Rate constant; Mechanism; τ1/2 (h); |
- 17640-02-7
methyl 2,2-dichloropropionate
- 100-52-7
benzaldehyde
A
- 80-63-7
methyl 2-chloroacrylate
B
- 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate
| Conditions | Yield |
|---|---|
| With boron trifluoride; zinc In tetrahydrofuran at 0℃; for 24h; | A 3 % Chromat. B 76 % Chromat. |
- 100-52-7
benzaldehyde
- 166666-36-0
methyl-α-bromo-α-chloro-propanoate
A
- 80-63-7
methyl 2-chloroacrylate
B
- 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate
| Conditions | Yield |
|---|---|
| With boron trifluoride; zinc In tetrahydrofuran at 0℃; for 3h; | A 1 % Chromat. B 85 % Chromat. C 8 % Chromat. |
Methyl 2-chloro-2-propenate Chemical Properties
Product Name: Methyl-2-chloroacrylate (CAS NO.80-63-7)
Molecular Formula: C4H5ClO2
Molecular Weight: 120.53g/mol
Mol File: 80-63-7.mol
Einecs: 201-298-7
Appearance: Clear colorless to pale yellow liquid
Boiling point: 124.6 °C at 760 mmHg
Storage Temperature: 0-6°C
Flash Point: 39.7 °C
Density: 1.155 g/cm3
Refractive index: 1.442-1.444
Surface Tension: 27.8 dyne/cm
Enthalpy of Vaporization: 36.25 kJ/mol
Vapour Pressure: 12.6 mmHg at 25°C
XLogP3-AA: 1.5
H-Bond Donor: 0
H-Bond Acceptor: 2
Product Categories: Monomer
Methyl 2-chloro-2-propenate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LC50 | inhalation | 500mg/m3/2H (500mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956. |
| guinea pig | LC50 | inhalation | 500mg/m3/2H (500mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956. |
| human | TCLo | inhalation | 5ppm (5ppm) | SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE | "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 90, 1968. |
| mouse | LC50 | inhalation | 500mg/m3/2H (500mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956. |
| rabbit | LC50 | inhalation | 500mg/m3/2H (500mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956. |
| rabbit | LD50 | skin | 270mg/kg (270mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" | National Technical Information Service. Vol. OTS0535234, |
| rat | LC50 | inhalation | 500mg/m3/2H (500mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956. |
| rat | LD50 | intraperitoneal | 27mg/kg (27mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" | National Technical Information Service. Vol. OTS0535234, |
| rat | LD50 | oral | 68mg/kg (68mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI | National Technical Information Service. Vol. OTS0535234 |
Methyl 2-chloro-2-propenate Consensus Reports
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
Methyl 2-chloro-2-propenate Safety Profile
Moderately toxic by inhalation. Human systemic effects by inhalation: conjunctiva irritation. A severe skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl−. See also ESTERS.
Safety Information of Methyl-2-chloroacrylate (CAS NO.80-63-7):
Hazard Codes: T+.gif){kind=small}
Risk Statements: 34-26-24/25-10
10: Flammable
24: Toxic in contact with skin
25: Toxic if swallowed
26: Very Toxic by inhalation
34: Causes burns
Safety Statements: 45-38-36/37/39-26-16
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
38: In case of insufficient ventilation, wear suitable respiratory equipment
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Methyl 2-chloro-2-propenate Specification
Methyl-2-chloroacrylate ,its CAS NO. is 80-63-7,the synonyms is 2-Chloro-2-propenoicacid,methylester ; 2-Chloro-2-propenoicacimethylester ; 2-Chloroacrylic acid, methyl ester ; 2-Chloroacrylicacid,methylester ; 2-Chloro-acrylicacimethylester ; 2-Chloropropenoic acid, methyl ester ; 2-Propenoic acid, 2-chloro-, methyl ester ; Acrylic acid, 2-chloro-, methyl ester .
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