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Methylazoxymethyl acetate

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Methylazoxymethyl acetate

EINECS 209-765-7
CAS No. 592-62-1 Density 1.18g/cm3
PSA 67.41000 LogP 0.62250
Solubility 22,000 mg l-1 (e) Melting Point N/A
Formula C4H8 N2 O3 Boiling Point 179.2°Cat760mmHg
Molecular Weight 132.119 Flash Point 62.2°C
Transport Information N/A Appearance N/A
Safety Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS. Risk Codes 45-61
Molecular Structure Molecular Structure of 592-62-1 (METHYLAZOXY METHANOL ACETATE) Hazard Symbols T
Synonyms

Methanol,(methyl-ONN-azoxy)-, acetate (ester) (8CI,9CI);Methanol, (methylazoxy)-,acetate (ester) (7CI);Methylazoxymethanol acetate;Methylazoxymethyl acetate;NSC 87705;

 

Methylazoxymethyl acetate Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 121.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Methylazoxymethyl acetate Specification

Methylazoxymethanol acetate( CAS No.592-62-1) is also called (methyl-onn-azoxy)-methanoacetate(ester); (methyl-onn-azoxy)methanol,acetate(ester); (methyl-onn-azoxy)methanol,acetateester;aceticacid,(methyl-onn-azoxy)methylester; cycasinacetate; mamac; mamacetate; methylazoxymethanolacetate. Methylazoxymethanol acetate, MAM, is a neurotoxin and carcinogen which reduces DNA synthesis used in making animal models of neurological diseases including schizophrenia and epilepsy. Methylazoxymethyl acetate is used as a potent alkylating agent. It is an azo compound. Azo, compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids.

Physical properties about Methylazoxymethanol acetate are: (1)ACD/LogP: 0.691; (2)#H bond acceptors:5; (3)#Freely Rotating Bonds: 3; (4)Index of Refraction:1.463; (5)Molar Refractivity: 30.708 cm3; (6)Molar Volume: 111.513 cm3; (7)Polarizability: 12.174 10-24cm3; (8)Surface Tension: 38.6980018615723 dyne/cm; (9)Density: 1.185 g/cm3; (10)Flash Point: 62.153 °C; (11)Enthalpy of Vaporization: 41.544 kJ/mol; (12)Boiling Point: 179.158 °C at 760 mmHg; (13)Vapour Pressure: 0.954999983310699 mmHg at 25°C

You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H8N2O3/c1-4(7)9-3-5-6(2)8/h3H2,1-2H3/b6-5+;
(2)InChIKey=BELPJCDYWUCHKF-AATRIKPKSA-N;
(3)SmilesC(OC\N=[N+](/C)[O-])(C)=O

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 105mg/kg (105mg/kg)   JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse LD50 intravenous 10mg/kg (10mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04566,
mouse LDLo oral 35mg/kg (35mg/kg)   Cancer Research. Vol. 30, Pg. 801, 1970.
 
rat LDLo intraperitoneal 50mg/kg (50mg/kg)   Chemico-Biological Interactions. Vol. 17, Pg. 291, 1977.
 

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