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Cas Database |
| Name |
N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester |
EINECS | 1592732-453-0 |
| CAS No. | 157115-85-0 | Density | 1.202g/cm3 |
| PSA | 75.71000 | LogP | 1.22820 |
| Solubility | N/A | Melting Point |
94.0 to 98.0 °C |
| Formula | C17H22N2O4 | Boiling Point | 547.3°Cat760mmHg |
| Molecular Weight | 318.373 | Flash Point | 284.8°C |
| Transport Information | N/A | Appearance | white powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Glycine,1-(phenylacetyl)-L-prolyl-, ethyl ester (9CI);Glycine,N-[1-(phenylacetyl)-L-prolyl]-, ethyl ester;GVS 111;Glycine,1-(2-phenylacetyl)-L-prolyl-, ethyl ester;SGS 111;Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester; |
Article Data | 1 |
N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Synthetic route
- 623-33-6
glycine ethyl ester hydrochloride
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine In chloroform; N,N-dimethyl-formamide at -5 - 20℃; for 1.5h; Yield given; |
- 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme |
- 103-80-0
phenylacetyl chloride
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C 2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme |
- 147-85-3
L-proline
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C 2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme |
- 74-89-5
methylamine
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| In methanol Ambient temperature; | 99% |
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| With ammonia In methanol Ambient temperature; | 95% |
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
- 157115-95-2
N-phenylacetyl-L-prolylglycine
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 3h; | 89.9% |
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 89.9 percent / 1 N aq. NaOH / 3 h 2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C 3: dimethylformamide / 0.5 h / -5 °C View Scheme |
- 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 89.9 percent / 1 N aq. NaOH / 3 h 2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C View Scheme |
N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Chemical Properties
IUPAC Name: Ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
Synonyms of Noopept (CAS NO.157115-85-0): ethyl phenylacetyl-Pro-Gly ; GVS 111 ; GVS-111 ; Glycine, N-(1-(phenylacetyl)-L-prolyl)-, ethyl ester ; Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester
CAS NO: 157115-85-0
Classification Code: Nootropic
Molecular Formula of Noopept (CAS NO.157115-85-0): C17H22N2O4
Molecular Weight: 318.3676
Molecular Structure:
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Polar Surface Area: 66.92 Å2
Index of Refraction: 1.548
Molar Refractivity: 84.17 cm3
Molar Volume: 264.7 cm3
Surface Tension: 49.7 dyne/cm
Density: 1.202 g/cm3
Flash Point: 284.8 °C
Enthalpy of Vaporization: 82.67 kJ/mol
Boiling Point: 547.3 °C at 760 mmHg
Vapour Pressure: 4.93E-12 mmHg at 25°C
N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Uses
Noopept (CAS NO.157115-85-0) is a drug promotion. It is from the drugs and share similar mechanisms of action, racetam family income, but up to 1,000 times higher than the prototype racetam potent drug, piracetam. Animal studies have shown noopept is to protect and enhance neurological test different memory. Unusual is that peptides derived compounds, noopept also showed oral bioavailability and good blood-brain barrier permeability, and human studies have shown promising and the treatment of Alzheimer's disease has a potential application of the results.
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