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Name	N-(2-Hydroxyethyl)stearamide	EINECS	203-883-2
CAS No.	111-57-9	Density	0.905 g/cm³
PSA	49.33000	LogP	5.74730
Solubility	1mg/L at 20℃	Melting Point	103-104 °C(Solv: ethanol (64-17-5))
Formula	C₂₀H₄₁NO₂	Boiling Point	486.034 °C at 760 mmHg
Molecular Weight	327.551	Flash Point	247.744 °C
Transport Information	N/A	Appearance	N/A
Safety	22-24/25	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Monoethanolstearamide;N-(2-Hydroxyethyl)octadecanamide;N-(2-Hydroxyethyl)stearamide;N-Octadecanoylethanolamine;N-Stearoylethanolamine;NSC 3377;Stearic ethanolamide;Stearicethylolamide;Stearic monoethanolamide;Stearic monoethanolamine;Stearoylmonoethanolamide;	Article Data	33

N-(2-Hydroxyethyl)stearamide Synthetic route

: 141-43-5
ethanolamine

: 57-11-4
stearic acid

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
Stage #1: stearic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h; Stage #2: ethanolamine In dichloromethane for 12h;	96%
Stage #1: stearic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 4h; Stage #2: ethanolamine In ethanol at 20℃; for 0.5h; Inert atmosphere;	95.5%
Stage #1: stearic acid With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile at 20℃; for 0.166667h; Inert atmosphere; Stage #2: ethanolamine In dichloromethane; acetonitrile at 20℃; Inert atmosphere;	90%

: 111-63-7
vinyl stearate

: 141-43-5
ethanolamine

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
With sodium methylate at 80℃; for 1h; Neat (no solvent);	95.4%
With sodium methylate at 80℃; for 1h; Concentration; Temperature; Time; Solvent;	95.4%

: 141-43-5
ethanolamine

: 112-76-5
Stearoyl chloride

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 4.5h;	95%
In tetrahydrofuran at 0 - 20℃; for 2h;	81%
In tetrahydrofuran at 0 - 20℃; for 2h;	81%

: 14464-32-5
stearic acid N-hydroxysuccinimide ester

: 141-43-5
ethanolamine

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2.5h;	88%

: 141-43-5
ethanolamine

: 124-26-5
stearamide

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
Stage #1: stearamide With triethylamine; methyl chloroformate In dichloromethane at 0 - 20℃; for 2h; Stage #2: ethanolamine In dichloromethane at 0 - 20℃; for 20h;	74%

: 111-63-7
vinyl stearate

: 141-43-5
ethanolamine

A: 10287-60-2
O-stearoylethanolamine

B: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
With Novozym 435 In hexane at 45℃; for 5h; Enzymatic reaction;	A 17.4% B 72.3%
With Candida antarctica lipase for 20h; Concentration; Time; Enzymatic reaction;	A 26.5% B 61.6%

: 10287-60-2
O-stearoylethanolamine

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
at 20℃; Geschwindigkeit der Umlagerung in wss. Loesung vom pH 7.5 und 10;

: 111-61-5
stearic acid ethyl ester

: 141-43-5
ethanolamine

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
at 160℃; unter Abdestillieren des gebildeten Wassers;

: C20H38O4

: 141-43-5
ethanolamine

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
In dichloromethane at 20℃; Cooling with ice;

: 57-11-4
stearic acid

: 111-57-9
N-stearoylethanolamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid 2: acetonitrile / 24 h View Scheme

N-(2-Hydroxyethyl)stearamide Chemical Properties

Molecular Structure:

Molecular Formula: C₂₀H₄₁NO₂
Molecular Weight: 327.545
IUPAC Name: N-(2-Hydroxyethyl)octadecanamide
Synonyms of Octadecanamide,N-(2-hydroxyethyl)- (CAS NO.111-57-9): Clindrol 200-MS ; Comperlan HS ; Cycloamide SM ; EINECS 203-883-2 ; Loramine S 280 ; Marlamid M 18 ; Monoethanolamine stearic acid amide ; N-(2-Hydroxyethyl)octadecanamide ; N-(2-Hydroxyethyl)stearamide ; N-(Hydroxyethyl)stearamide ; N-Stearoylethanolamine ; NSC 3377 ; Onyx Wax EL ; Stearamide MEA ; Stearamyl ; Stearic acid monoethanolamide ; Stearic ethanolamide ; Stearic ethylolamide ; Stearic monoethanolamide ; Stearic monoethanolamine ; Stearoylethanolamine ; Stearoylmonoethanolamide
CAS NO: 111-57-9
Index of Refraction: 1.463
Molar Refractivity: 99.86 cm³
Molar Volume: 362.1 cm³
Surface Tension: 34.4 dyne/cm
Density: 0.904 g/cm³
Flash Point: 247.7 °C
Enthalpy of Vaporization: 86.61 kJ/mol
Boiling Point: 486 °C at 760 mmHg
Vapour Pressure: 1.74E-11 mmHg at 25°C

N-(2-Hydroxyethyl)stearamide Safety Profile

Safety Statements of Octadecanamide,N-(2-hydroxyethyl)- (CAS NO.111-57-9): 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2

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